Managing antibiotic resistance is a significant challenge in modern pharmacotherapy. While
molecular analyses have identified efflux pump expression as an essential mechanism …

Efflux is an important mechanism in Gram-negative bacteria conferring multidrug resistance.
Inhibition of efflux is an encouraging strategy to restore the antibacterial activity of antibiotics …

Drug efflux pumps confer multidrug resistance to dangerous bacterial pathogens which
makes these proteins promising drug targets. Herein, we present initial chemical …

In bacteria, multidrug-resistance pumps (MDRs) confer resistance to chemically unrelated
amphipathic toxins. A major challenge in developing efficacious antibiotics is identifying …

Antibiotic resistance poses an immediate and growing threat to human health. Multidrug
efflux pumps are promising targets for overcoming antibiotic resistance with small-molecule …

The current global antimicrobial resistance (AMR) crisis is a serious hazard to public health,
food security, and development. Drug-resistant pathogens diminish the effectiveness of …

The increasing multi-drug resistance has become a major threat to the public health.
Overexpression of multidrug efflux pumps is one of the major mechanisms of drug resistance …

Antimicrobial resistance is becoming a paramount health concern nowadays. The
increasing drug resistance in microbes is due to improper medications or over usage of …

Drug efflux mechanisms interact synergistically with the outer membrane permeability
barrier of Gram-negative bacteria, leading to intrinsic resistance that presents a major …

Efflux mechanisms have become broadly recognized as major components of resistance to
many classes of antibiotics. Some efflux pumps selectively extrude specific antibiotics, while …