Hybrid antimicrobials containing an antibacterial linked to a multidrug resistance (MDR)
pump inhibitor make up a promising new class of agents for countering efflux-mediated …

Antibiotic resistance is recognized globally as an emerging threat for public health. The
recent World Health Organization report identifies an array of multidrug resistant bacterial …

Multidrug–resistant Escherichia coli is a continuously growing worldwide public health
problem, in which the well-known AcrAB-TolC tripartite RND efflux pump is a critical driver …

An in-depth evaluation was undertaken of a new antibacterial natural product (1) recently
isolated and characterised from the plant Hypericum olympicum L. cf. uniflorum. Minimum …

Bacteria express a plethora of efflux pumps that can transport structurally varied molecules,
including antimicrobial agents and antibiotics, out of cells. Thus, efflux pump systems …

Efflux pumps of the resistance-nodulation division superfamily, such as AcrB, make a major
contribution to multidrug resistance in Gram-negative bacteria. Inhibitors of such pumps …

Pseudomonas aeruginosa is resistant to a wide range of antibiotics, thus making
troublesome the infection treatment. Efflux systems are the main mechanisms involved; …

In Gram-negative bacteria, efflux complexes, consisting of an inner-membrane pump, a
periplasmic adaptor protein and outer-membrane channel, provide an efficient means for the …

Multidrug‐resistant pathogens are a significant clinical problem. Efflux pump inhibitors
(EPIs) can restore the activities of existing antibiotics by interfering with drug efflux pumps …

The drug accumulation of a human multidrug resistance 1 (mdr1) gene-transfected mouse
lymphoma cell line and a multidrug resistance protein (MRP)-expressing human breast …