A compendium of global gene expression measurements from DNA microarray analysis of
immune cells identifies gene expression signatures defining various lineages, differentiation …

Gene expression variation is critical for the normal development and physiology of immune
cells. Using cDNA microarrays, a systematic, genomic-scale view of gene expression in …

Genomics has provided a lever to pry open lymphoid cells and examine their regulatory
biology. The large body of available gene expression data has also allowed us to define the …

T and B lymphocytes are developmentally and functionally related cells of the immune
system, representing the two major branches of adaptive immunity. Although originating …

The identity and abundance of mRNA species within a cell dictate, to a large extent, the
biological potential of that cell. Although posttranscriptional mechanisms modify protein …

Gene expression microarrays: glimpses of the immunological genome | Nature Immunology
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72 ALIZADEH ET AL. receptor to bind the antigen. The centrocytes that can still bind antigen
are rescued from programmed cell death and may either re-enter the proliferative …

Background The specialisation of mammalian cells in time and space requires genes
associated with specific pathways and functions to be co-ordinately expressed. Here we …

Self-tolerance is achieved by deleting or regulating self-reactive lymphocytes at a series of
cellular checkpoints placed at many points along the developmental pathways to plasma …

High-capacity methods for assessing gene function have become increasingly important
because of the increasing number of newly identified genes emerging from large-scale …