Breakthrough: Chloroquine phosphate has shown apparent efficacy in treatment of COVID-19 associated pneumonia in clinical studies

J Gao, Z Tian, X Yang - Bioscience trends, 2020 - jstage.jst.go.jp
Abstract The coronavirus disease 2019 (COVID-19) virus is spreading rapidly, and scientists
are endeavoring to discover drugs for its efficacious treatment in China. Chloroquine …

[HTML][HTML] Drug repurposing in COVID-19: a review with past, present and future

K Srivastava, MK Singh - Metabolism Open, 2021 - Elsevier
The coronavirus SARS-CoV-2 which causes the COVID-19 disease is a global public health
emergency. Coronavirus are single-stranded positive-sense RNA viruses and their genome …

[HTML][HTML] Clinical efficacy of chloroquine derivatives in COVID-19 infection: comparative meta-analysis between the big data and the real world

M Million, P Gautret, P Colson, Y Roussel… - New Microbes and New …, 2020 - Elsevier
In the context of the current coronavirus disease 2019 (COVID-19) pandemic, we conducted
a meta-analysis on the effects of chloroquine derivatives in patients, based on unpublished …

Hydroxychloroquine as an aerosol might markedly reduce and even prevent severe clinical symptoms after SARS-CoV-2 infection

A Klimke, G Hefner, B Will, U Voss - Medical hypotheses, 2020 - Elsevier
Covid-19 is a new coronavirus disease first described in December 2019. This respiratory
illness is severe and potentially fatal. Severe cases make up to 15%, lethality ranges …

Pharmacokinetics and pharmacological properties of chloroquine and hydroxychloroquine in the context of COVID‐19 infection

MR Nicol, A Joshi, ML Rizk, PE Sabato… - Clinical …, 2020 - Wiley Online Library
Chloroquine and hydroxychloroquine are quinoline derivatives used to treat malaria. To
date, these medications are not approved for the treatment of viral infections, and there are …

Chloroquine as a potential treatment and prevention measure for the 2019 novel coronavirus: a review

J Kearney - 2020 - preprints.org
There is a long trail of research studies testing the in vitro and in vivo efficacy of chloroquine
and its derivatives in treating and preventing infection by various coronavirus species. More …

Colchicine treatment can improve outcomes of coronavirus disease 2019 (COVID‐19): a systematic review and meta‐analysis

TI Hariyanto, DA Halim, C Jodhinata… - Clinical and …, 2021 - Wiley Online Library
Currently, there is no widely acceptable and proven effective treatment for coronavirus
disease 2019 (COVID‐19). Colchicine has been shown to offer a benefit in reducing the …

Clozapine treatment and risk of COVID-19 infection: retrospective cohort study

R Govind, DF de Freitas, M Pritchard… - The British journal of …, 2021 - cambridge.org
BackgroundClozapine, an antipsychotic with unique efficacy in treatment-resistant
psychosis, is associated with increased susceptibility to infection, including pneumonia …

Sequential doxycycline and colchicine combination therapy in Covid-19: the salutary effects

HM Al-Kuraishy, AI Al-Gareeb, N Qusty… - Pulmonary …, 2021 - Elsevier
Abstract Coronavirus virus disease 2019 (COVID-19) is a viral infectious disease caused by
the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), actually considered as …

Chloroquine and hydroxychloroquine for COVID‐19: Perspectives on their failure in repurposing

RR Shah - Journal of clinical pharmacy and therapeutics, 2021 - Wiley Online Library
What is known and Objective Non‐clinical studies suggest that chloroquine (CQ) and
hydroxychloroquine (HCQ) have antiviral activities. Early clinical reports of successful HCQ …