Targeting the human cancer pathway protein interaction network by structural genomics
Structural genomics provides an important approach for characterizing and understanding
systems biology. As a step toward better integrating protein three-dimensional (3D) …
systems biology. As a step toward better integrating protein three-dimensional (3D) …
[HTML][HTML] Crystal structure of human retinoblastoma binding protein 9 (RBBP9)
SM Vorobiev, M Su, J Seetharaman, YJ Huang… - Proteins, 2009 - ncbi.nlm.nih.gov
As a step towards better integrating protein three-dimensional (3D) structural information in
cancer systems biology, the Northeast Structural Genomics Consortium (NESG)(www. nesg …
cancer systems biology, the Northeast Structural Genomics Consortium (NESG)(www. nesg …
[PDF][PDF] The role of protein interaction domains in the human cancer network
Protein-protein interaction networks provide a global picture of cellular function and
biological processes. Proteins interact largely through specific domains which constitute the …
biological processes. Proteins interact largely through specific domains which constitute the …
Human cancer protein-protein interaction network: a structural perspective
Protein-protein interaction networks provide a global picture of cellular function and
biological processes. Some proteins act as hub proteins, highly connected to others …
biological processes. Some proteins act as hub proteins, highly connected to others …
Tools for protein-protein interaction network analysis in cancer research
R Sanz-Pamplona, A Berenguer, X Sole… - Clinical and …, 2012 - Springer
As cancer is a complex disease, the representation of a malignant cell as a protein-protein
interaction network (PPIN) and its subsequent analysis can provide insight into the …
interaction network (PPIN) and its subsequent analysis can provide insight into the …
Probabilistic model of the human protein-protein interaction network
A catalog of all human protein-protein interactions would provide scientists with a framework
to study protein deregulation in complex diseases such as cancer. Here we demonstrate that …
to study protein deregulation in complex diseases such as cancer. Here we demonstrate that …
Oncoprotein-specific molecular interaction maps (SigMaps) for cancer network analyses
Tumor-specific elucidation of physical and functional oncoprotein interactions could improve
tumorigenic mechanism characterization and therapeutic response prediction. Current …
tumorigenic mechanism characterization and therapeutic response prediction. Current …
A human functional protein interaction network and its application to cancer data analysis
Background One challenge facing biologists is to tease out useful information from massive
data sets for further analysis. A pathway-based analysis may shed light by projecting …
data sets for further analysis. A pathway-based analysis may shed light by projecting …
Pan-cancer mapping of differential protein-protein interactions
Deciphering the variations in the protein interactome is required to reach a systems-level
understanding of tumorigenesis. To accomplish this task, we have considered the clinical …
understanding of tumorigenesis. To accomplish this task, we have considered the clinical …
Global topological features of cancer proteins in the human interactome
PF Jonsson, PA Bates - Bioinformatics, 2006 - academic.oup.com
Motivation: The study of interactomes, or networks of protein-protein interactions, is
increasingly providing valuable information on biological systems. Here we report a study of …
increasingly providing valuable information on biological systems. Here we report a study of …