Cloning by somatic cell nuclear transfer requires that epigenetic information possessed by
the donor nucleus be reprogrammed to an embryonic state. Little is known, however, about …

Genomic imprinting requires the differential marking by DNA methylation of genes in male
and female gametes. In the female germline, acquisition of methylation imprint marks …

The first mammalian DNA methyltransferase to be identified was cloned by chromatographic
purification of the protein to homogeneity, determination of the sequence of cyanogen …

Virtually all mammalian species including mouse, rat, pig, cow, and human, but not sheep
and rabbit, undergo genome‐wide epigenetic reprogramming by demethylation of the male …

A subset of genes, known as imprinted genes, is present in the mammalian genome.
Genomic imprinting governs the monoallelic expression of these genes, depending on …

It has been a controversial issue as to how many DNA cytosine methyltransferase
mammalian cells have and whether de novo methylation and maintenance methylation …

Abstract Changes in DNA methylation profiles are common features of development and in a
number of human diseases, such as cancer and imprinting disorders like Beckwith …

The occurrence of 5-methylcytosine in DNA was first described in 1948 by Hotchkiss (see
first chapter). Recognition of its possible physiologi cal role in eucaryotes was first …

Maintenance of genomic methylation patterns in mammalian somatic cells depends on DNA
methyltransferase-1 (Dnmt1). Mouse oocytes and preimplantation embryos lack Dnmt1 but …

Epigenetics refers to covalent modifications of DNA and core histones that regulate gene
activity without altering DNA sequence. To date, the best‐characterized DNA modification …