The occurrence of 5-methylcytosine in DNA was first described in 1948 by Hotchkiss (see
first chapter). Recognition of its possible physiologi cal role in eucaryotes was first …

Imprinted genes have patterns of expression that depend on the parent of origin of their
alleles. Establishment of imprinting at a locus requires that the two alleles be differentially …

Methyl-accepting assays and a sensitive method for labeling specific CpG sites have been
used to show that the DNA of F9 embryonal carcinoma cells decreases in 5-methylcytosine …

DNA methyltransferase is needed for normal development, perhaps because DNA
methylation plays a part in the control of gene activity. It is clear that the methylation of …

DNA methylation is a crucial epigenetic modification of the genome that is involved in
regulating many cellular processes. These include embryonic development, transcription …

To determine the methylation status of female germ cells in reference to the programmed
reversal of X chromosome inactivation in these cells, we examined human fetal ovaries at …

DNA-mediated gene transfer was used to investigate the mode of inheritance of 5-
methylcytosine in mouse L cells. Unmethylated phi X174 replicative form DNA remains …

DNA methylation plays an important role in the regulation of gene expression during
development. Methyl moieties at CpG residues suppress transcription by affecting DNA …

The reprogramming of parental methylomes is essential for embryonic development. In
mammals, paternal 5-methylcytosines (5mCs) have been proposed to be actively converted …

DNA methylation inhibits gene expression in animal cells, probably by affecting chromatin
structure. Biochemical studies suggest that this process may be mediated by methyl-specific …