Carnosine and related compounds were compared in terms of their abilities to decrease the
levels of reactive oxygen species (ROS) in suspensions of isolated neurons activated by N …

Two novel derivatives of carnosine—(S)-trolox-l-carnosine (STC) and (R)-trolox-l-carnosine
(RTC) are characterized in terms of their antioxidant and membrane-stabilizing activities as …

Carnosine, anserine, and homocarnosine are endogenous dipeptides concentrated in brain
and muscle whose biological functions remain in doubt. 2. We have tested the hypothesis …

Carnosine and taurine have been suggested to protect excitable tissues against oxidative
stress. We have investigated the protection of cerebellar granule cells (neurons) by these …

The development of neuroprotective drugs against ischemic insults is hampered by the lack
of pharmacological in vitro models. We developed an ischemic model using PC12 cell …

1. The biological effects of carnosine, a natural hydrophilic neuropeptide, on the reactive
oxygen species (ROS) pathological generation are reviewed. 2. We describe direct …

Carnosine, a specific constituent of excitable tissues of vertebrates, exhibits a significant
antioxidant protecting effect on the brain damaged by ischemic-reperfusion injury when it …

1. The ability of carnosine and carnosine-related compounds (CRCs) to interact with several
free oxygen radicals is analyzed. 2. Carnosine, the CRCs (imidazole, histidine, anserine) …

The main aim of this new book is to summarise the knowledge on the metabolic
transformation of carnosine in excitable tissues of animals and human beings and to …

The role of carnosine, N-acetylcarnosine and homocarnosine as scavengers of reactive
oxygen species and protectors against neuronal cell death secondary to excitotoxic …