A randomized controlled trial to prevent post-operative atrial fibrillation by antioxidant reinforcement

R Rodrigo, P Korantzopoulos, M Cereceda… - Journal of the American …, 2013 - jacc.org
Objectives: This study was designed to assess whether the reinforcement of the antioxidant
system, through n-3 fatty acids plus antioxidant vitamin supplementation, could reduce the …

Oxidative stress biomarkers and incidence of postoperative atrial fibrillation in the omega‐3 fatty acids for prevention of postoperative atrial fibrillation (OPERA) trial

JHY Wu, R Marchioli, MG Silletta… - Journal of the …, 2015 - Am Heart Assoc
Background Animal study results point to oxidative stress as a key mechanism triggering
postoperative atrial fibrillation (Po AF), yet the extent to which specific biomarkers of …

Ageing improves the antioxidant response against postoperative atrial fibrillation: a randomized controlled trial

R Rodrigo, R Gutiérrez, R Fernández… - … and thoracic surgery, 2012 - academic.oup.com
OBJECTIVES Extracorporeal circulation is associated with ischaemia–reperfusion-induced
oxidative stress and atrial fibrillation (AF). Ageing is the major risk factor for this arrhythmia …

Do antioxidant vitamins have an anti-arrhythmic effect following cardiac surgery? A meta-analysis of randomised controlled trials

L Harling, S Rasoli, JA Vecht, H Ashrafian… - Heart, 2011 - heart.bmj.com
Background Postoperative atrial fibrillation (POAF) affects approximately 30% of patients
undergoing elective cardiac surgery. While its pathogenesis is multifactorial, increasing …

Antioxidant supplementations for prevention of atrial fibrillation after cardiac surgery: an updated comprehensive systematic review and meta-analysis of 23 …

S Ali-Hassan-Sayegh, SJ Mirhosseini… - … and thoracic surgery, 2014 - academic.oup.com
This systematic review with meta-analysis sought to determine the impact of antioxidants (N-
acetylcysteine [NAC], polyunsaturated fatty acids [PUFAs] and vitamins) on incidence of …

Prevention of postoperative atrial fibrillation: novel and safe strategy based on the modulation of the antioxidant system

R Rodrigo - Frontiers in physiology, 2012 - frontiersin.org
Postoperative atrial fibrillation (AF) is the most common arrhythmia following cardiac surgery
with extracorporeal circulation. The pathogenesis of postoperative AF is multifactorial …

Oxidative stress and atrial fibrillation after cardiac surgery: a case-control study

B Ramlawi, H Otu, S Mieno, M Boodhwani… - The Annals of thoracic …, 2007 - Elsevier
BACKGROUND: New-onset postoperative atrial fibrillation (PAF) continues to be among the
most common complications after cardiac surgery, leading to significant morbidity and cost …

The role of ascorbic acid in the prevention of atrial fibrillation after elective on-pump myocardial revascularization surgery: a single-center experience–a pilot study

P Papoulidis, O Ananiadou… - … and thoracic surgery, 2011 - academic.oup.com
Atrial fibrillation (AF) is a common arrhythmia that occurs postoperatively in cardiac surgery.
There is evidence for the role of oxidative stress in the etiology of AF. In our study, we …

Tracing the origins of postoperative atrial fibrillation: the concept of oxidative stress-mediated myocardial injury phenomenon

MM Elahi, S Flatman… - European Journal of …, 2008 - journals.sagepub.com
Background Atrial fibrillation (AF) is the most common arrhythmia associated with coronary
artery surgery and is an important factor contributing to postoperative morbidity and …

Antioxidant supplementation attenuates oxidative stress in patients undergoing coronary artery bypass graft surgery

O Stanger, I Aigner, W Schimetta… - The Tohoku journal of …, 2014 - jstage.jst.go.jp
Ischemia-reperfusion has been reported to be associated with augmented oxidative stress in
the course of surgery, which might be causally involved in the onset of atrial fibrillation (AF) …