In recent years, the different classes of drugs and regimens used clinically have provided an
improvement in tumour management. However, treatment is often palliative for the majority …

The mechanism of action of chemotherapeutic drugs and their ability to induce multidrug
resistance (MDR) are of relevance to cancer treatment. Overexpression of P-glycoprotein …

Background The acquisition of resistance to chemotherapy is a major hurdle in the
successful application of cancer therapy. Several anticancer approaches, including …

Drug resistance genes, such as MDR1, involved in drug efflux, and their regulation have
been the subject of intense research efforts in the past 10 years. Many factors and cellular …

Selection of human cells for resistance to vincristine or doxorubicin often induces
overexpression of the multidrug resistance 1 gene (MDR1), which encodes the cell surface …

Methylation of CpG dinucleotides is one of the major epigenetic processes involved in the
regulation of gene expression. Catalyzed by DNA methyltransferases, hypermethylation of …

The resistance of cancer cells to chemotherapeutic agents is a major clinical problem and
an important cause of treatment failure in cancer. Mechanisms that have developed to guard …

The development of multidrug resistance (MDR) in cancer can severely impede the efficacy
of chemotherapy treatment. P-glycoprotein (Pgp) overexpression, encoded by the MDR1 …

Chemotherapeutic drug resistance is a major clinical problem and cause for failure in the
therapy of human cancer. One of the goals of molecular oncology is to identify the …

Overexpression of the human multidrug resistance gene 1 (MDR1) is a negative prognostic
factor in leukemia. Despite intense efforts to characterize the gene at the molecular level …