In vitro and in silico evaluation of antiproliferative activity of new isoxazolidine derivatives targeting EGFR: design, synthesis, cell cycle analysis, and apoptotic …
A series of novel enantiopure isoxazolidine derivatives were synthesized and evaluated for
their anticancer activities against three human cancer cell lines such as human breast …
their anticancer activities against three human cancer cell lines such as human breast …
Novel thioxoimidazolidinone derivatives as dual EGFR and CDK2 inhibitors: Design, synthesis, anticancer evaluation with in silico study
AY Hassan, MA El Deeb, MS El-Zoghbi… - Journal of Molecular …, 2023 - Elsevier
Fifteen thioxoimidazolidinone derivatives were designed as dual EGFR and CDK2 inhibitors
and synthesized following Claisen and Knoevenagel condensation. Derivative 12 showed …
and synthesized following Claisen and Knoevenagel condensation. Derivative 12 showed …
Quinoline‐based thiazolidinone derivatives as potent cytotoxic and apoptosis‐inducing agents through EGFR inhibition
Quinoline‐based thiazolidinone heterocycles exhibited potent activity in the field of cancer
therapy. Hence, ten quinoline‐based thiazolidinone derivatives were evaluated for their …
therapy. Hence, ten quinoline‐based thiazolidinone derivatives were evaluated for their …
Design, synthesis, and docking studies of quinazoline analogues bearing aryl semicarbazone scaffolds as potent EGFR inhibitors
Two series of quinazoline derivatives bearing aryl semicarbazone scaffolds (9a–o and 10a–
o) were designed, synthesized and evaluated for the IC 50 values against four cancer cell …
o) were designed, synthesized and evaluated for the IC 50 values against four cancer cell …
EGFR/VEGFR-2 dual inhibitor and apoptotic inducer: Design, synthesis, anticancer activity and docking study of new 2-thioxoimidazolidin-4one derivatives
AAE Mourad, NA Farouk, ESH El-Sayed, ARE Mahdy - Life Sciences, 2021 - Elsevier
Aims EGFR and VEGFR-2 have emerged as promising targets for cancer management as
they play a crucial role in tumor growth, angiogenesis and metastasis. A novel series of 2 …
they play a crucial role in tumor growth, angiogenesis and metastasis. A novel series of 2 …
New pyrimidine-5-carbonitrile derivatives as EGFR inhibitors with anticancer and apoptotic activities: design, molecular modeling and synthesis
IA Osman, RR Ayyad, HA Mahdy - New Journal of Chemistry, 2022 - pubs.rsc.org
In connection with our efforts in the development of new anticancer agents, herein we report
the design and synthesis of new small pyrimidine-5-carbonitrile based derivatives. The …
the design and synthesis of new small pyrimidine-5-carbonitrile based derivatives. The …
Design, synthesis, biological evaluation, QSAR analysis and molecular modelling of new thiazol-benzimidazoles as EGFR inhibitors
AM Srour, NS Ahmed, SS Abd El-Karim… - Bioorganic & Medicinal …, 2020 - Elsevier
Heterocyclic rings such as thiazole and benzimidazole are considered as privileged
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …
structures, since they constitute several FDA-approved drugs for cancer treatment. In this …
New series of isoxazole derivatives targeting EGFR-TK: Synthesis, molecular modeling and antitumor evaluation
New series of isoxazole derivatives were synthesized and evaluated for in vitro antitumor
activity against HepG2, MCF-7 and HCT-116 cancer cells. Results showed that 4b and 25a …
activity against HepG2, MCF-7 and HCT-116 cancer cells. Results showed that 4b and 25a …
Naproxen based 1, 3, 4-oxadiazole derivatives as EGFR inhibitors: Design, synthesis, anticancer, and computational studies
MM Alam, S Nazreen, ASA Almalki, AA Elhenawy… - Pharmaceuticals, 2021 - mdpi.com
A library of novel naproxen based 1, 3, 4-oxadiazole derivatives (8–16 and 19–26) has been
synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized …
synthesized and screened for cytotoxicity as EGFR inhibitors. Among the synthesized …
Design, synthesis, anticancer activity and molecular docking of novel 1H-benzo [d] imidazole derivatives as potential EGFR inhibitors
CE Theodore, G Sivaiah, SBB Prasad… - Journal of Molecular …, 2023 - Elsevier
Here, we present the design, synthesis, and evaluation of a new series of 1H-benzo [d]
imidazole derivatives (10a–j) to determine their anticancer efficacy. The MCF-7 and HCT116 …
imidazole derivatives (10a–j) to determine their anticancer efficacy. The MCF-7 and HCT116 …