Pharmacological treatment of abdominal aortic aneurysm

T Miyake, R Morishita - Cardiovascular research, 2009 - academic.oup.com
Abdominal aortic aneurysm (AAA) is a common degenerative condition with high mortality in
older men. Elective surgical or endovascular repair is performed to prevent rupture of large …

Current status and perspectives on pharmacologic therapy for abdominal aortic aneurysm

K Yoshimura, N Morikage… - Current drug …, 2018 - ingentaconnect.com
Background: Abdominal aortic aneurysm (AAA), a common disease involving the segmental
expansion and rupture of the aorta, has a high mortality rate. Therapeutic options for AAA …

Pathogenesis and management of abdominal aortic aneurysm

J Golledge, S Thanigaimani, JT Powell… - European Heart …, 2023 - academic.oup.com
Abdominal aortic aneurysm (AAA) causes∼ 170 000 deaths annually worldwide. Most
guidelines recommend asymptomatic small AAAs (30 to< 50 mm in women; 30 to< 55 mm in …

[HTML][HTML] Challenges and opportunities in limiting abdominal aortic aneurysm growth

J Golledge, PE Norman, MP Murphy… - Journal of vascular …, 2017 - Elsevier
Objective This review describes ongoing efforts to develop a medical therapy to limit
abdominal aortic aneurysm (AAA) growth. Methods Data from animal model studies, human …

[HTML][HTML] Novel pharmacological approaches in abdominal aortic aneurysm

L Puertas-Umbert, R Almendra-Pegueros… - Clinical …, 2023 - portlandpress.com
Abdominal aortic aneurysm (AAA) is a severe vascular disease and a major public health
issue with an unmet medical need for therapy. This disease is featured by a progressive …

[HTML][HTML] Experimental models of abdominal aortic aneurysms

JC Tsui - The open cardiovascular medicine journal, 2010 - ncbi.nlm.nih.gov
Despite being a leading cause of death in the West, the pathophysiology of abdominal aortic
aneurysms (AAA) is still incompletely understood. Pharmacotherapy to reduce the growth of …

Lack of an effective drug therapy for abdominal aortic aneurysm

J Golledge, JV Moxon, TP Singh… - Journal of internal …, 2020 - Wiley Online Library
Abdominal aortic aneurysm (AAA) rupture is a common cause of death in adults. Current
AAA treatment is by open surgical or endovascular aneurysm repair. Rodent model and …

Pharmacological therapy of abdominal aortic aneurysm: an update

Y Wang, Z Liu, J Ren, M Xiang - Current vascular …, 2018 - ingentaconnect.com
Background: Abdominal aortic aneurysm (AAA), a progressive segmental abdominal aortic
dilation, is associated with high mortality. AAA is characterized by inflammation, smooth …

[HTML][HTML] Editor's Choice–pharmaceutical management of small abdominal aortic aneurysms: a systematic review of the clinical evidence

VBC Kokje, JF Hamming, JHN Lindeman - European Journal of Vascular …, 2015 - Elsevier
Background Management of abdominal aortic aneurysms (AAAs) relies on surgical repair of
larger AAAs. Consequently medical interventions inhibiting AAA progression could greatly …

Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm

B Liu, DJ Granville, J Golledge… - American Journal of …, 2020 - journals.physiology.org
Aortic aneurysm is a permanent focal dilation of the aorta. It is usually an asymptomatic
disease but can lead to sudden death due to aortic rupture. Aortic aneurysm-related …