Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic
mutations and loss of tumor suppressors. Mounting evidence indicates that altered …

Metabolism rewiring is an important hallmark of cancers. Being one of the most abundant
free amino acids in the human blood, glutamine supports bioenergetics and biosynthesis …

Metabolic reprogramming in cancer targets glutamine metabolism as a key mechanism to
provide energy, biosynthetic precursors and redox requirements to allow the massive …

Simple Summary Dysregulated glutamine metabolism is one of the metabolic features
evident in cancer cells when compared to normal cells. Cancer cells utilize glutamine for …

Highlights•Inhibition of glutamine metabolism is an important mechanism in cancer
control.•Novel drugs offer a mechanism by which the key metabolic enzyme glutaminase …

Targeting glutamine catabolism has been attracting more research attention on the
development of successful cancer therapy. Catalytic enzymes such as glutaminase (GLS) in …

Altered cellular metabolism is a hallmark of cancer. Cancer cells express isoforms of
metabolic enzymes that may constitute therapeutic targets. Glutaminase controls glutamine …

The metabolic adaptations that support oncogenic growth can also render cancer cells
dependent on certain nutrients. Along with the Warburg effect, increased utilization of …

Advances in cell metabolism over the past few decades have demonstrated glutamine as an
essential nutrient for cancer cell survival and proliferation. Glutamine offers a remarkable …

Glutamine is the most abundant circulating amino acid in blood and muscle and is critical for
many fundamental cell functions in cancer cells, including synthesis of metabolites that …