The development of multidrug resistance (MDR) in cancer can severely impede the efficacy
of chemotherapy treatment. P-glycoprotein (Pgp) overexpression, encoded by the MDR1 …

The mechanism of action of chemotherapeutic drugs and their ability to induce multidrug
resistance (MDR) are of relevance to cancer treatment. Overexpression of P-glycoprotein …

Drug resistance genes, such as MDR1, involved in drug efflux, and their regulation have
been the subject of intense research efforts in the past 10 years. Many factors and cellular …

The emergence of resistance in a tumor population is most often associated with a
disregulation of gene expression, usually at the level of transcription. A major goal in the …

Pleiotropic resistance of tumor cells to treatment remains one of the major obstacles for
successful cure of cancer patients. Tumor cells may acquire multidrug resistance (MDR) in …

Two decades ago, the overexpression of P-glycoprotein (Pgp) was first demonstrated to
mediate the energy-dependent efflux of a variety of chemotherapeutic agents from tumor …

Overexpression of the multidrug resistance 1 (MDR1) gene is closely associated with the
clinical outcome of hematopoietic malignancies, but the alteration of its expression during …

Drug resistance is one of the major obstacles in the treatment of various cancers. Since
chemotherapy serves as a most beneficial method for the repression of tumor progression …

The resistance of tumors to a number of structurally and functionally unrelated
chemotherapeutic drugs has been a major obstacle for successful cancer chemotherapy. An …

Although combination chemotherapy has had a significant impact on survival for
malignancies such as Hodgkin's disease, testicular cancer, and childhood acute leukemias …