Integrated stability and activity control of the Drosophila Rbf1 retinoblastoma protein
The retinoblastoma (RB) family transcriptional corepressors regulate diverse cellular events
including cell cycle, senescence, and differentiation. The activity and stability of these …
including cell cycle, senescence, and differentiation. The activity and stability of these …
Role of Drosophila retinoblastoma protein instability element in cell growth and proliferation
JS Elenbaas, R Mouawad, RW Henry, DN Arnosti… - Cell cycle, 2015 - Taylor & Francis
The RB tumor suppressor, a regulator of the cell cycle, apoptosis, senescence, and
differentiation, is frequently mutated in human cancers. We recently described an …
differentiation, is frequently mutated in human cancers. We recently described an …
Diversification of retinoblastoma protein function associated with cis and trans adaptations
Retinoblastoma proteins are eukaryotic transcriptional corepressors that play central roles in
cell cycle control, among other functions. Although most metazoan genomes encode a …
cell cycle control, among other functions. Although most metazoan genomes encode a …
Paradoxical instability–activity relationship defines a novel regulatory pathway for retinoblastoma proteins
The Retinoblastoma (RB) transcriptional corepressor and related family of pocket proteins
play central roles in cell cycle control and development, and the regulatory networks …
play central roles in cell cycle control and development, and the regulatory networks …
Ubiquitination of retinoblastoma family protein 1 potentiates gene-specific repression function
The retinoblastoma (RB) tumor suppressor family functions as a regulatory node governing
cell cycle progression, differentiation, and apoptosis. Post-translational modifications play a …
cell cycle progression, differentiation, and apoptosis. Post-translational modifications play a …
Distinct developmental expression of Drosophila retinoblastoma factors
SA Keller, Z Ullah, MS Buckley, RW Henry… - Gene expression …, 2005 - Elsevier
Retinoblastoma (RB) tumor suppressor proteins are important regulators of the cell cycle
and are implicated in a wide variety of human tumors. Genetic analysis of RB mutations in …
and are implicated in a wide variety of human tumors. Genetic analysis of RB mutations in …
Evidence for Autoregulation and Cell Signaling Pathway Regulation From Genome-Wide Binding of the Drosophila Retinoblastoma Protein
The retinoblastoma (RB) tumor suppressor protein is a transcriptional cofactor with essential
roles in cell cycle and development. Physical and functional targets of RB and its paralogs …
roles in cell cycle and development. Physical and functional targets of RB and its paralogs …
The evolutionarily conserved C-terminal domains in the mammalian retinoblastoma tumor suppressor family serve as dual regulators of protein stability and …
S Sengupta, R Lingnurkar, TS Carey… - Journal of Biological …, 2015 - ASBMB
The retinoblastoma (RB) tumor suppressor and related family of proteins play critical roles in
development through their regulation of genes involved in cell fate. Multiple regulatory …
development through their regulation of genes involved in cell fate. Multiple regulatory …
Structures of inactive retinoblastoma protein reveal multiple mechanisms for cell cycle control
Cyclin-dependent kinase (Cdk) phosphorylation of the Retinoblastoma protein (Rb) drives
cell proliferation through inhibition of Rb complexes with E2F transcription factors and other …
cell proliferation through inhibition of Rb complexes with E2F transcription factors and other …
The Rb/E2F pathway: expanding roles and emerging paradigms
JW Harbour, DC Dean - Genes & development, 2000 - genesdev.cshlp.org
The retinoblastoma gene was identified over a decade ago as the first tumor suppressor.
Although the gene was initially cloned as a result of its frequent mutation in the rare pediatric …
Although the gene was initially cloned as a result of its frequent mutation in the rare pediatric …