Evidence is emerging that several diseases and behavioral pathologies result from defects
in gene function. The best-studied example is cancer, but other diseases such as …

Epigenetics is a molecular phenomenon that pertains to heritable changes in gene
expression that do not involve changes in the DNA sequence. Epigenetic modifications in a …

The fundamental role of altered epigenetic modification patterns in tumorigenesis
establishes epigenetic regulatory enzymes as important targets for cancer therapy. Over the …

Epigenetic changes are defined as inherited modifications that are not present in DNA
sequence. Gene expression is regulated at various levels and not only in response to DNA …

Abnormalities in the epigenetic regulation of chromatin structure and function can lead to
aberrant gene expression and cancer development. Consequently, epigenetic therapies aim …

Epigenetics refers to heritable molecular determinants of phenotype independent of DNA
sequence. Epigenetic features include DNA methylation, histone modifications, non-coding …

In addition to the genetic alterations, observed in cancer cells, are mitotically heritable
changes in gene expression not encoded by the DNA sequences, which are referred to as …

Epigenetic changes such as DNA methylation and histone methylation and acetylation alter
gene expression at the level of transcription by upregulating, downregulating, or silencing …

Histone proteins are subject to a diverse range of post-translational modifications which,
along with DNA methylation, play a major role in controlling gene expression, cell division …

In the last three decades huge efforts have been made to characterize genetic defects
responsible for cancer development and progression, leading to the comprehensive …