5-HT1A< 5.1 5-HT2C< 4.8 5-HT1B< 5.3 5-HT4< 5.0 5-HT1D 5.5 5-HT6< 4.8 5-HT1E< 4.8 5-
HT7 7.5 (0.04 (n) 6) 5-HT1F< 5.2 adrenergic R1B< 4.8 5-HT2A< 4.8 dopaminergic D2 5.4 5 …

Here we report the synthesis of N-(1, 2, 3, 4-tetrahydronaphthalen-1-yl)-4-aryl-1-
piperazinealkylamides 16− 29 that were designed to elucidate both structure− affinity and …

The 5-hydroxytryptamine (5-HT, serotonin) superfamily of receptors currently consists of 7
classes (5-HT1-5-HT7) that embrace 14 human subclasses. 1 The most recent addition is …

Introduction. The human 5-HT7 receptor is a recently discovered member of the seven-
transmembrane G-protein-coupled receptor superfamily. 2 The most abundant isoform 5 …

SB‐258585 (4‐Iodo‐N‐[4‐methoxy‐3‐(4‐methyl‐piperazin‐1‐yl)‐phenyl]‐
benzenesulphonamide) is a high affinity ligand at 5‐HT6 receptors. It displays over 100 fold …

The selective 5-HT7 receptor antagonist radioligand,[3H]-SB-269970, has been reported to
radiolabel the human cloned 5-HT7 (a) receptor and 5-HT7 receptors in guinea pig cortex …

Substituted N-phenyl-4-methoxy-3-piperazin-1-ylbenzenesulfonamides and
conformationally restricted analogues have been identified as high affinity and selective 5 …

Arylsulfonyl analogs of aminopyrimidines (eg Ro 04-6790; 2), aminopyridines (eg Ro 63-
0563; 3), 1-phenylpiperazines (eg SB-271046; 4), and tryptamines (eg MS-245; 5) were …

A series of potent 5-hydroxytryptamine7 (5-HT7) ligands has been synthesized that contain
a 1, 3-dihydro-2 H-indol-2-one (oxindole) skeleton. The binding of these compounds to the 5 …

Radiotracers suitable for positron emission tomography studies often serve as preclinical
tools for in vivo receptor occupancy. The serotonin 1B receptor (5-HT1B) subtype is a …