[HTML][HTML] Disruption of human plasma cell differentiation by an environmental polycyclic aromatic hydrocarbon: a mechanistic immunotoxicological study
LL Allan, DH Sherr - Environmental Health, 2010 - Springer
Abstract Background The AhR is a ligand-activated transcription factor that mediates
immunosuppression induced by environmental PAH and HAH. Recently, a critical role for …
immunosuppression induced by environmental PAH and HAH. Recently, a critical role for …
Integrin α4 up-regulation activates the hedgehog pathway to promote arsenic and benzo [α] pyrene co-exposure-induced cancer stem cell-like property and …
Arsenic and benzo [α] pyrene (BaP) are widespread carcinogens and important etiology
factors for lung cancer. Moreover, arsenic and BaP co-exposure displays a significantly …
factors for lung cancer. Moreover, arsenic and BaP co-exposure displays a significantly …
Benzo [a] pyrene activates an AhR/Src/ERK axis that contributes to CYP1A1 induction and stable DNA adducts formation in lung cells
G Vázquez-Gómez, L Rocha-Zavaleta… - Toxicology letters, 2018 - Elsevier
Abstract Benzo [a] pyrene (B [a] P), the most extensively studied carcinogen in cigarette
smoke, has been regarded as a critical mediator of lung cancer. It is known that B [a] P …
smoke, has been regarded as a critical mediator of lung cancer. It is known that B [a] P …
[HTML][HTML] Polycyclic aromatic hydrocarbon-induced signaling events relevant to inflammation and tumorigenesis in lung cells are dependent on molecular structure
Polycyclic aromatic hydrocarbons (PAHs) are ubiquitous environmental and occupational
toxicants, which are a major human health concern in the US and abroad. Previous research …
toxicants, which are a major human health concern in the US and abroad. Previous research …
Importance of CYP1A1 and CYP1B1 in bioactivation of benzo [a] pyrene in human lung cell lines
H Uppstad, S Øvrebø, A Haugen, S Mollerup - Toxicology letters, 2010 - Elsevier
Polycyclic aromatic hydrocarbons are ubiquitous environmental pollutants classified as
carcinogens in humans and rodents. The cytochromes P4501A1 and 1B1 have both shown …
carcinogens in humans and rodents. The cytochromes P4501A1 and 1B1 have both shown …
In vitro malignant transformation of human bronchial epithelial cells induced by benzo (a) pyrene
P Zhao, J Fu, B Yao, Y Song, L Mi, Z Li, L Shang… - Toxicology in Vitro, 2012 - Elsevier
In this study, the human bronchial epithelial cells (16HBE) were treated five times with 10μM
benzo (a) pyrene (BaP), followed by 20 passages culture, and the in vitro BaP-induced …
benzo (a) pyrene (BaP), followed by 20 passages culture, and the in vitro BaP-induced …
Modulation of benzo [a] pyrene induced immunotoxicity in mice actively immunized with a B [a] P-diphtheria toxoid conjugate
MT Schellenberger, N Grova, S Willième… - Toxicology and applied …, 2009 - Elsevier
Benzo [a] pyrene (B [a] P) is a small molecular weight carcinogen and the prototype of
polycyclic aromatic hydrocarbons (PAHs). While these compounds are primarily known for …
polycyclic aromatic hydrocarbons (PAHs). While these compounds are primarily known for …
Tumor necrosis factor-α potentiates genotoxic effects of benzo [a] pyrene in rat liver epithelial cells through upregulation of cytochrome P450 1B1 expression
L Umannová, M Machala, J Topinka… - Mutation Research …, 2008 - Elsevier
Benzo [a] pyrene (BaP) is a ubiquitous environmental pollutant, which may contribute to the
development of human cancer. The ultimate carcinogenic BaP metabolite produced by …
development of human cancer. The ultimate carcinogenic BaP metabolite produced by …
Comparative mechanisms of PAH toxicity by benzo [a] pyrene and dibenzo [def, p] chrysene in primary human bronchial epithelial cells cultured at air-liquid interface
Y Chang, LK Siddens, LK Heine, DA Sampson… - Toxicology and applied …, 2019 - Elsevier
Current assumption for assessing carcinogenic risk of polycyclic aromatic hydrocarbons
(PAHs) is that they function through a common mechanism of action; however, recent …
(PAHs) is that they function through a common mechanism of action; however, recent …
[HTML][HTML] The carcinogenic properties of overlooked yet prevalent polycyclic aromatic hydrocarbons in human lung epithelial cells
AK Bauer, KJ Siegrist, M Wolff, L Nield, T Brüning… - Toxics, 2022 - mdpi.com
The WHO classified air pollution as a human lung carcinogen and polycyclic aromatic
hydrocarbons (PAHs) are components of both indoor (eg, tobacco smoke and cookstoves) …
hydrocarbons (PAHs) are components of both indoor (eg, tobacco smoke and cookstoves) …