Rational drug design strategies for the development of promising multi-target directed indole hybrids as Anti-Alzheimer agents

N George, MJ Akhtar, KA Al Balushi, SA Khan - Bioorganic Chemistry, 2022 - Elsevier
Alzheimer's disease (AD) is a neurological disorder that leads to dementia ie, progressive
memory loss accompanied with worsening of thinking ability of an individual. The cause of …

Multi-target directed drugs as a modern approach for drug design towards Alzheimer's disease: an update

M de Freitas Silva, KST Dias, VS Gontijo… - Current Medicinal …, 2018 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive multifactorial neurodegenerative disorder.
Currently, no effective treatment is available and this is due to multiple factors involved in …

A comprehensive review of multi-target directed ligands in the treatment of Alzheimer's disease

C Pathak, UD Kabra - Bioorganic Chemistry, 2024 - Elsevier
Alzheimer's disease (AD) is the most common form of dementia affecting specifically older
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …

Novel multitarget hybrid compounds for the treatment of Alzheimer's disease

P Michalska, I Buendia, L Barrio… - Current Topics in …, 2017 - ingentaconnect.com
Alzheimer's disease (AD) is the most prevalent among the aging diseases known as
neurodegenerative disorders. Drug design programs over the last two decades were mainly …

Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands

L Blaikie, G Kay, PKT Lin - MedChemComm, 2019 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and a major
cause of death worldwide. The number of people suffering from this debilitating disorder is …

Indole-Based Compounds in the Development of Anti-Neurodegenerative Agents

E Barresi, E Baglini, V Poggetti, J Castagnoli… - Molecules, 2024 - mdpi.com
Neurodegeneration is a gradual decay process leading to the depletion of neurons in both
the central and peripheral nervous systems, ultimately resulting in cognitive dysfunctions …

Multi-target-directed ligands as an effective strategy for the treatment of Alzheimer's disease

B Kumar, A Thakur, AR Dwivedi… - Current Medicinal …, 2022 - ingentaconnect.com
Alzheimer's disease (AD) is a complex neurological disorder and multiple pathological
factors are believed to be involved in the genesis and progression of the disease. A number …

Multi-target directed drugs: a modern approach for design of new drugs for the treatment of Alzheimer's disease

K Simone Tranches Dias… - Current …, 2014 - ingentaconnect.com
Alzheimer's disease (AD) is a complex neurodegenerative disorder with a multi-faceted
pathogenesis. So far, the therapeutic paradigm “one-compound-one-target” has failed and …

Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease

N Kumar, V Kumar, P Anand, V Kumar… - Bioorganic & Medicinal …, 2022 - Elsevier
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …

Effects of linkers and substitutions on multitarget directed ligands for Alzheimer's diseases: Emerging paradigms and strategies

N Pravin, K Jozwiak - International journal of molecular sciences, 2022 - mdpi.com
Alzheimer's disease (AD) is multifactorial, progressive and the most predominant cause of
cognitive impairment and dementia worldwide. The current “one-drug, one-target” approach …