Rational drug design strategies for the development of promising multi-target directed indole hybrids as Anti-Alzheimer agents
Alzheimer's disease (AD) is a neurological disorder that leads to dementia ie, progressive
memory loss accompanied with worsening of thinking ability of an individual. The cause of …
memory loss accompanied with worsening of thinking ability of an individual. The cause of …
Multi-target directed drugs as a modern approach for drug design towards Alzheimer's disease: an update
M de Freitas Silva, KST Dias, VS Gontijo… - Current Medicinal …, 2018 - ingentaconnect.com
Alzheimer's disease (AD) is a progressive multifactorial neurodegenerative disorder.
Currently, no effective treatment is available and this is due to multiple factors involved in …
Currently, no effective treatment is available and this is due to multiple factors involved in …
A comprehensive review of multi-target directed ligands in the treatment of Alzheimer's disease
Alzheimer's disease (AD) is the most common form of dementia affecting specifically older
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …
population. AD is an irreversible neurodegenerative CNS disorder associated with complex …
Novel multitarget hybrid compounds for the treatment of Alzheimer's disease
P Michalska, I Buendia, L Barrio… - Current Topics in …, 2017 - ingentaconnect.com
Alzheimer's disease (AD) is the most prevalent among the aging diseases known as
neurodegenerative disorders. Drug design programs over the last two decades were mainly …
neurodegenerative disorders. Drug design programs over the last two decades were mainly …
Current and emerging therapeutic targets of alzheimer's disease for the design of multi-target directed ligands
L Blaikie, G Kay, PKT Lin - MedChemComm, 2019 - pubs.rsc.org
Alzheimer's disease (AD) is the most prevalent neurodegenerative disease, and a major
cause of death worldwide. The number of people suffering from this debilitating disorder is …
cause of death worldwide. The number of people suffering from this debilitating disorder is …
Indole-Based Compounds in the Development of Anti-Neurodegenerative Agents
E Barresi, E Baglini, V Poggetti, J Castagnoli… - Molecules, 2024 - mdpi.com
Neurodegeneration is a gradual decay process leading to the depletion of neurons in both
the central and peripheral nervous systems, ultimately resulting in cognitive dysfunctions …
the central and peripheral nervous systems, ultimately resulting in cognitive dysfunctions …
Multi-target-directed ligands as an effective strategy for the treatment of Alzheimer's disease
B Kumar, A Thakur, AR Dwivedi… - Current Medicinal …, 2022 - ingentaconnect.com
Alzheimer's disease (AD) is a complex neurological disorder and multiple pathological
factors are believed to be involved in the genesis and progression of the disease. A number …
factors are believed to be involved in the genesis and progression of the disease. A number …
Multi-target directed drugs: a modern approach for design of new drugs for the treatment of Alzheimer's disease
K Simone Tranches Dias… - Current …, 2014 - ingentaconnect.com
Alzheimer's disease (AD) is a complex neurodegenerative disorder with a multi-faceted
pathogenesis. So far, the therapeutic paradigm “one-compound-one-target” has failed and …
pathogenesis. So far, the therapeutic paradigm “one-compound-one-target” has failed and …
Advancements in the development of multi-target directed ligands for the treatment of Alzheimer's disease
Alzheimer's disease (AD) is a multifactorial irreversible neurological disorder which results
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
in cognitive impairment, loss of cholinergic neurons in synapses of the basal forebrain and …
Effects of linkers and substitutions on multitarget directed ligands for Alzheimer's diseases: Emerging paradigms and strategies
N Pravin, K Jozwiak - International journal of molecular sciences, 2022 - mdpi.com
Alzheimer's disease (AD) is multifactorial, progressive and the most predominant cause of
cognitive impairment and dementia worldwide. The current “one-drug, one-target” approach …
cognitive impairment and dementia worldwide. The current “one-drug, one-target” approach …