Induction of reproductive tract developmental abnormalities in the male rat by lowering androgen production or action in combination with a low dose of …
A Rivas, JS Fisher, C McKinnell, N Atanassova… - …, 2002 - academic.oup.com
This study tested the hypothesis that testis/reproductive tract abnormalities induced in the rat
by neonatal treatment with diethylstilbestrol (DES) result from disturbance of the androgen …
by neonatal treatment with diethylstilbestrol (DES) result from disturbance of the androgen …
Suppression of androgen action and the induction of gross abnormalities of the reproductive tract in male rats treated neonatally with diethylstilbestrol
C McKinnell, N Atanassova, K Williams… - Journal of …, 2001 - Wiley Online Library
This study evaluated whether androgen action is altered in rats treated neonatally with
diethylstilbestrol (DES) at a dose that induced reproductive tract abnormalities. Rats were …
diethylstilbestrol (DES) at a dose that induced reproductive tract abnormalities. Rats were …
Neonatal coadministration of testosterone with diethylstilbestrol prevents diethylstilbestrol induction of most reproductive tract abnormalities in male rats
A Rivas, C McKinnell, JS Fisher… - Journal of …, 2003 - Wiley Online Library
The primary purpose of this study was to evaluate whether the coadministration of
testosterone (TE; 200 μg) with 10 μg of diethylstilbestrol (DES) between days 2 and 12 …
testosterone (TE; 200 μg) with 10 μg of diethylstilbestrol (DES) between days 2 and 12 …
Effects of neonatal administration of diethylstilbestrol in male hamsters: disruption of reproductive function in adults after apparently normal pubertal development
SA Khan, RB Ball, WJ Hendry III - Biology of Reproduction, 1998 - academic.oup.com
Prenatal and neonatal exposure to natural and synthetic estrogens induces developmental
abnormalities in the male and female reproductive systems in several species. In hamsters …
abnormalities in the male and female reproductive systems in several species. In hamsters …
Abnormalities in functional development of the Sertoli cells in rats treated neonatally with diethylstilbestrol: a possible role for estrogens in Sertoli cell development
RM Sharpe, N Atanassova, C McKinnell… - Biology of …, 1998 - academic.oup.com
Diethylstilbestrol (DES) was administered neonatally (Days 2–12; 10 μg on alternate days)
to rats, and developmental changes in Sertoli cell function were evaluated at 18, 25, and 35 …
to rats, and developmental changes in Sertoli cell function were evaluated at 18, 25, and 35 …
Induction of estrogen receptor and cell division in genital tracts of male mice by neonatal exposure to diethylstilbestrol
T Sato, A Chiba, S Hayashi, H Okamura, Y Ohta… - Reproductive …, 1994 - Elsevier
Estrogen receptor (ER) and ER mRNA expression and cell division induced by neonatal
diethylstilbestrol (DES) exposure in male C57BL/Tw mouse genital organs were studied …
diethylstilbestrol (DES) exposure in male C57BL/Tw mouse genital organs were studied …
Effects of maternal exposure to a low dose of diethylstilbestrol on sexual dimorphic nucleus volume and male reproductive system in rat offspring
M Yamamoto, M Shirai, A Tamura… - The Journal of …, 2005 - jstage.jst.go.jp
Diethylstilbestrol (DES) was administered subcutaneously at 0.5, 1.5 or 4.5 µg/kg/day (DES
0.5, 1.5 and 4.5 groups, respectively) to pregnant SD rats daily on days 7-21 of gestation, to …
0.5, 1.5 and 4.5 groups, respectively) to pregnant SD rats daily on days 7-21 of gestation, to …
Neonatal exposure to potent and environmental oestrogens and abnormalities of the male reproductive system in the rat: evidence for importance of the androgen …
K Williams, C McKinnell, PTK Saunders… - Human reproduction …, 2001 - academic.oup.com
The effects on reproductive tract development in male rats, of neonatal exposure to potent
(reference) oestrogens, diethylstilboestrol (DES) and ethinyl oestradiol (EE), with those of …
(reference) oestrogens, diethylstilboestrol (DES) and ethinyl oestradiol (EE), with those of …
The effects of androgens on fetal sexual development: Androgen-induced female pseudohermaphrodism
MM Grumbach, JR Ducharme - Fertility and sterility, 1960 - Elsevier
IN ANY CONSIDERATION of the effects of androgens on the fetal organism, it is important
that the term" androgen" be defined. An androgen is usually regarded as a steroid which, in …
that the term" androgen" be defined. An androgen is usually regarded as a steroid which, in …
Altered sexual development in male rats after oestrogen administration during the neonatal period
K Brown-Grant, G Fink, F Greig, MAF Murray - Reproduction, 1975 - rep.bioscientifica.com
Male rats given 250 μg oestradiol benzoate by subcutaneous injection on Day 4 of postnatal
life showed a marked delay in the onset of the pubertal increase in the weight of the testes …
life showed a marked delay in the onset of the pubertal increase in the weight of the testes …