The essential oil carvacrol from oregano displays a wide range of biological activities among
which is found the inhibition of efflux pumps. Thus, using carvacrol, the current work …

Berberine (BBR) is an effective drug for human intestinal inflammation by preventing
intestinal adhesion of bacterial pathogens, while its antibacterial activity is ineffective …

Extrusion of drugs or drug-like compounds through bacterial efflux pumps is a serious health
issue that leads to loss in drug efficacy. Combinatorial therapies of low-efficacy drugs with …

Chemical studies of Praxelis clematidea RM King & Robinson resulted in the isolation of six
flavones: Apigenine, genkwanine, 7, 4'-dimethylapigenin, trimethylapigenin, cirsimaritin and …

Previous research showed that berberine-containing Berberis species synthesise the
substances 5′-methoxyhydnocarpin-D (5′-MHC-D) and pheophorbide a, which have no …

Background: Carvacrol is an aromatic phenolic terpenoid widely existing in the volatile oils
of thyme, oregano, and some other aromatic plants. Recent studies have found that …

Several compounds isolated from the plant Carpobrotus edulis were evaluated for their
activity against multidrug-resistant (MDR) bacteria and their efflux pump systems. Amongst …

In bacteria, multidrug-resistance pumps (MDRs) confer resistance to chemically unrelated
amphipathic toxins. A major challenge in developing efficacious antibiotics is identifying …

One way that bacteria develop antibiotic resistance is by reducing intracellular antibiotic
concentrations through efflux pumps. Therefore, enhancing the efficacy of antibiotics using …

Background There is urgent need to discover new antimicrobial compounds with diverse
chemical structures and mechanisms of action due to increasing new and re-emerging …