Microglial brain region− dependent diversity and selective regional sensitivities to aging
Microglia have critical roles in neural development, homeostasis and neuroinflammation
and are increasingly implicated in age-related neurological dysfunction. Neurodegeneration …
and are increasingly implicated in age-related neurological dysfunction. Neurodegeneration …
Single-cell RNA sequencing of microglia throughout the mouse lifespan and in the injured brain reveals complex cell-state changes
Microglia, the resident immune cells of the brain, rapidly change states in response to their
environment, but we lack molecular and functional signatures of different microglial …
environment, but we lack molecular and functional signatures of different microglial …
Transcriptional and epigenetic decoding of the microglial aging process
As important immune cells, microglia undergo a series of alterations during aging that
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …
Microglia phenotypes converge in aging and neurodegenerative disease
M Candlish, JK Hefendehl - Frontiers in neurology, 2021 - frontiersin.org
Microglia, the primary immune cells of the central nervous system, hold a multitude of tasks
in order to ensure brain homeostasis and are one of the best predictors of biological age on …
in order to ensure brain homeostasis and are one of the best predictors of biological age on …
Transcriptional landscape of human microglia implicates age, sex, and APOE‐related immunometabolic pathway perturbations
Microglia have fundamental roles in health and disease; however, effects of age, sex, and
genetic factors on human microglia have not been fully explored. We applied bulk and …
genetic factors on human microglia have not been fully explored. We applied bulk and …
Human microglia show unique transcriptional changes in Alzheimer's disease
Microglia, the innate immune cells of the brain, influence Alzheimer's disease (AD)
progression and are potential therapeutic targets. However, microglia exhibit diverse …
progression and are potential therapeutic targets. However, microglia exhibit diverse …
Transcriptomic analysis of purified human cortical microglia reveals age-associated changes
Microglia are essential for CNS homeostasis and innate neuroimmune function, and play
important roles in neurodegeneration and brain aging. Here we present gene expression …
important roles in neurodegeneration and brain aging. Here we present gene expression …
The transcriptional landscape of microglial genes in aging and neurodegenerative disease
LW Bonham, DW Sirkis, JS Yokoyama - Frontiers in immunology, 2019 - frontiersin.org
Microglia, the brain-resident myeloid cells, are strongly implicated in Alzheimer's disease
(AD) pathogenesis by human genetics. However, the mechanisms by which microglial gene …
(AD) pathogenesis by human genetics. However, the mechanisms by which microglial gene …
[HTML][HTML] Cross-species single-cell analysis reveals divergence of the primate microglia program
Microglia, the brain-resident immune cells, are critically involved in many physiological and
pathological brain processes, including neurodegeneration. Here we characterize microglia …
pathological brain processes, including neurodegeneration. Here we characterize microglia …
Mapping microglia states in the human brain through the integration of high-dimensional techniques
Microglia are tissue-resident macrophages of the CNS that orchestrate local immune
responses and contribute to several neurological and psychiatric diseases. Little is known …
responses and contribute to several neurological and psychiatric diseases. Little is known …