Vascular smooth muscle cell senescence plays a pivotal role in the pathogenesis of
atherosclerosis. Anagliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor for the …

Background Dipeptidyl peptidase 4 (DPP-4) inhibitors have been used to treat type 2
diabetes mellitus (T2DM) via inhibition of the enzymatic activity of DPP-4 in degrading active …

Cellular senescence is one of the most significant factors involved in aging and age-related
diseases. Senescence of vascular smooth muscle cells (VSMCs) adversely affects the …

Aging is a major risk factor for hypertension and atherosclerosis, and vascular smooth
muscle cell (VSMC) senescence can promote aging‐related vascular diseases. Sirtuin‐1 …

Abstract Dipeptidyl peptidase-4 (DPP4) is elevated in numerous cardiovascular pathological
processes and DPP4 inhibition is associated with reduced inflammation and oxidative …

Rationale: Uncontrolled growth of abdominal aortic aneurysms (AAAs) is a life-threatening
vascular disease without an effective pharmaceutical treatment. AAA incidence dramatically …

Diabetic nephropathy is one of the most important chronic microvascular complications of
diabetes, and its main feature is diabetic glomerulosclerosis. Endothelial sirtuin 1 (SIRT1) …

Objective—α7 nicotinic acetylcholine receptor (α7nAChR) is a subtype of nAChR and has
been reported to be involved in hypertension end-organ damage. In this study, we tested the …

Tetrahydroxystilbene glucoside (TSG), an active ingredient of Polygonum multiflorum, has
been known for certain anti-aging effects. In this study, the possible protective mechanism of …

Cardiovascular diseases (CVDs) are a major cause of death worldwide. Due to the
prevalence of many side effects and incomplete recovery from pharmacotherapies, stem cell …