Anagliptin prevented interleukin 1β (IL-1β)-induced cellular senescence in vascular smooth muscle cells through increasing the expression of sirtuin1 (SIRT1)
J Zhao, X He, M Zuo, X Li, Z Sun - Bioengineered, 2021 - Taylor & Francis
Vascular smooth muscle cell senescence plays a pivotal role in the pathogenesis of
atherosclerosis. Anagliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor for the …
atherosclerosis. Anagliptin is a novel dipeptidyl peptidase-4 (DPP-4) inhibitor for the …
[HTML][HTML] Effects of anagliptin on the stress induced accelerated senescence of human umbilical vein endothelial cells
SM Kang, HS Jung, MJ Kwon, SH Lee… - Annals of Translational …, 2021 - ncbi.nlm.nih.gov
Background Dipeptidyl peptidase 4 (DPP-4) inhibitors have been used to treat type 2
diabetes mellitus (T2DM) via inhibition of the enzymatic activity of DPP-4 in degrading active …
diabetes mellitus (T2DM) via inhibition of the enzymatic activity of DPP-4 in degrading active …
Omarigliptin prevents TNF-α-induced cellular senescence in rat aorta vascular smooth muscle cells
X Zhang, J Yuan, N Zhou, K Shen, Y Wang… - Chemical Research …, 2021 - ACS Publications
Cellular senescence is one of the most significant factors involved in aging and age-related
diseases. Senescence of vascular smooth muscle cells (VSMCs) adversely affects the …
diseases. Senescence of vascular smooth muscle cells (VSMCs) adversely affects the …
SRT1720‐induced activation of SIRT1 alleviates vascular smooth muscle cell senescence through PKA‐dependent phosphorylation of AMPKα at Ser485
JY Sung, SG Kim, DH Cho, JR Kim, HC Choi - FEBS Open Bio, 2020 - Wiley Online Library
Aging is a major risk factor for hypertension and atherosclerosis, and vascular smooth
muscle cell (VSMC) senescence can promote aging‐related vascular diseases. Sirtuin‐1 …
muscle cell (VSMC) senescence can promote aging‐related vascular diseases. Sirtuin‐1 …
Dipeptidyl peptidase-4 inhibition improves endothelial senescence by activating AMPK/SIRT1/Nrf2 signaling pathway
Z Chen, J Yu, M Fu, R Dong, Y Yang, J Luo… - Biochemical …, 2020 - Elsevier
Abstract Dipeptidyl peptidase-4 (DPP4) is elevated in numerous cardiovascular pathological
processes and DPP4 inhibition is associated with reduced inflammation and oxidative …
processes and DPP4 inhibition is associated with reduced inflammation and oxidative …
Age-associated sirtuin 1 reduction in vascular smooth muscle links vascular senescence and inflammation to abdominal aortic aneurysm
HZ Chen, F Wang, P Gao, JF Pei, Y Liu, TT Xu… - Circulation …, 2016 - Am Heart Assoc
Rationale: Uncontrolled growth of abdominal aortic aneurysms (AAAs) is a life-threatening
vascular disease without an effective pharmaceutical treatment. AAA incidence dramatically …
vascular disease without an effective pharmaceutical treatment. AAA incidence dramatically …
The inhibitory effects of Dulaglutide on cellular senescence against high glucose in human retinal endothelial cells
S Nian, Y Mi, K Ren, S Wang, M Li, D Yang - Human Cell, 2022 - Springer
Diabetic nephropathy is one of the most important chronic microvascular complications of
diabetes, and its main feature is diabetic glomerulosclerosis. Endothelial sirtuin 1 (SIRT1) …
diabetes, and its main feature is diabetic glomerulosclerosis. Endothelial sirtuin 1 (SIRT1) …
α7 Nicotinic Acetylcholine Receptor Relieves Angiotensin II–Induced Senescence in Vascular Smooth Muscle Cells by Raising Nicotinamide Adenine Dinucleotide …
DJ Li, F Huang, M Ni, H Fu, LS Zhang… - … , and Vascular Biology, 2016 - Am Heart Assoc
Objective—α7 nicotinic acetylcholine receptor (α7nAChR) is a subtype of nAChR and has
been reported to be involved in hypertension end-organ damage. In this study, we tested the …
been reported to be involved in hypertension end-organ damage. In this study, we tested the …
Tetrahydroxystilbene glucoside alleviates angiotensin II induced HUVEC senescence via SIRT1
W Fan, Y Guo, S Cao, S Cao, Y Xie… - Canadian journal of …, 2021 - cdnsciencepub.com
Tetrahydroxystilbene glucoside (TSG), an active ingredient of Polygonum multiflorum, has
been known for certain anti-aging effects. In this study, the possible protective mechanism of …
been known for certain anti-aging effects. In this study, the possible protective mechanism of …
MHY2233 Attenuates Replicative Cellular Senescence in Human Endothelial Progenitor Cells via SIRT1 Signaling
S Lamichane, SH Baek, YJ Kim, JH Park… - Oxidative medicine …, 2019 - Wiley Online Library
Cardiovascular diseases (CVDs) are a major cause of death worldwide. Due to the
prevalence of many side effects and incomplete recovery from pharmacotherapies, stem cell …
prevalence of many side effects and incomplete recovery from pharmacotherapies, stem cell …
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