A semi-empirical model to optimize continuous-flow hyperpolarized 129Xe production under practical cryogenic-accumulation conditions

JW Plummer, K Emami, A Dummer, JC Woods… - Journal of Magnetic …, 2020 - Elsevier
Continuous-flow spin exchange optical pumping (SEOP) with cryogenic accumulation is a
powerful technique to generate multiple, large volumes of hyperpolarized (HP) 129 Xe in …

Characterizing and modeling the efficiency limits in large-scale production of hyperpolarized

MS Freeman, K Emami, B Driehuys - Physical Review A, 2014 - APS
The ability to produce liter volumes of highly-spin-polarized Xe 129 enables a wide range of
investigations, most notably in the fields of materials science and biomedical magnetic …

Depolarization of nuclear spin polarized 129Xe gas by dark rubidium during spin-exchange optical pumping

MA Antonacci, A Burant, W Wagner… - Journal of Magnetic …, 2017 - Elsevier
Continuous-flow spin-exchange optical pumping (SEOP) continues to serve as the most
widespread method of polarizing 129 Xe for magnetic resonance experiments …

Multidimensional Mapping of Spin-Exchange Optical Pumping in Clinical-Scale Batch-Mode 129Xe Hyperpolarizers

P Nikolaou, AM Coffey, K Ranta… - The Journal of …, 2014 - ACS Publications
We present a systematic, multiparameter study of Rb/129Xe spin-exchange optical pumping
(SEOP) in the regimes of high xenon pressure and photon flux using a 3D-printed, clinical …

[HTML][HTML] Resolving the discrepancy between theoretical and experimental polarization of hyperpolarized 129Xe using numerical simulations and in situ optical …

M Kelley, A Burant, RT Branca - Journal of Applied Physics, 2020 - pubs.aip.org
For emerging biomedical applications of hyperpolarized xenon, the ability to obtain reliably
high nuclear spin polarization levels is paramount. Yet, experimental nuclear spin …

Interdependence of in-cell xenon density and temperature during Rb/129Xe spin-exchange optical pumping using VHG-narrowed laser diode arrays

N Whiting, P Nikolaou, NA Eschmann… - Journal of Magnetic …, 2011 - Elsevier
The 129Xe nuclear spin polarization (PXe) that can be achieved via spin-exchange optical
pumping (SEOP) is typically limited at high in-cell xenon densities ([Xe] cell), due primarily to …

[HTML][HTML] Pathway to cryogen free production of hyperpolarized krypton-83 and xenon-129

JS Six, T Hughes-Riley, KF Stupic, GE Pavlovskaya… - PLoS …, 2012 - journals.plos.org
Hyperpolarized (hp) 129Xe and hp 83Kr for magnetic resonance imaging (MRI) are typically
obtained through spin-exchange optical pumping (SEOP) in gas mixtures with dilute …

XeUS: A second-generation automated open-source batch-mode clinical-scale hyperpolarizer

JR Birchall, RK Irwin, P Nikolaou, AM Coffey… - Journal of Magnetic …, 2020 - Elsevier
We present a second-generation open-source automated batch-mode 129 Xe
hyperpolarizer (XeUS GEN-2), designed for clinical-scale hyperpolarized (HP) 129 Xe …

Portable Hyperpolarized Xe-129 Apparatus with Long-Time Stable Polarization Mediated by Adaptable Rb Vapor Density

R Stäglich, TW Kemnitzer, MC Harder… - The Journal of …, 2022 - ACS Publications
The extraordinary sensitivity of 129Xe, hyperpolarized by spin-exchange optical pumping, is
essential for magnetic resonance imaging and spectroscopy in life and materials sciences …

Helium-rich mixtures for improved batch-mode clinical-scale spin-exchange optical pumping of Xenon-129

JR Birchall, P Nikolaou, RK Irwin, MJ Barlow… - Journal of Magnetic …, 2020 - Elsevier
We present studies of spin-exchange optical pumping (SEOP) using ternary xenon-nitrogen-
helium gas mixtures at high xenon partial pressures (up to 1330áTorr partial pressure at …