Limitations and challenges in treatment of acute chemical warfare agent poisoning

H Thiermann, F Worek, K Kehe - Chemico-biological interactions, 2013 - Elsevier
Recent news from Syria on a possible use of chemical warfare agents made the headlines.
Furthermore, the motivation of terrorists to cause maximal harm shifts these agents into the …

Diagnostics and treatment of nerve agent poisoning—current status and future developments

N Amend, KV Niessen, T Seeger, T Wille… - Annals of the New …, 2020 - Wiley Online Library
Although 193 states have committed to the Chemical Weapons Convention and 98% of the
declared chemical weapons stockpiles have been destroyed so far, nerve agent poisoning …

The role of oximes in the treatment of nerve agent poisoning in civilian casualties

TC Marrs, P Rice, JA Vale - Toxicological reviews, 2006 - Springer
There are important differences between on-target military attacks against relatively well
protected Armed Forces and nerve agent attacks initiated by terrorists against a civilian …

Nerve agents

J Newmark - The neurologist, 2007 - journals.lww.com
Background: Nerve agents, the deadliest of the classic chemical warfare agents, primarily
function as acetylcholinesterase inhibitors and cause a rapidly progressive cholinergic …

Evolution of and perspectives on therapeutic approaches to nerve agent poisoning

P Masson - Toxicology letters, 2011 - Elsevier
After more than 70 years of considerable efforts, research on medical defense against nerve
agents has come to a standstill. Major progress in medical countermeasures was achieved …

Lessons to be learnt from organophosphorus pesticide poisoning for the treatment of nerve agent poisoning

H Thiermann, L Szinicz, P Eyer, N Felgenhauer… - Toxicology, 2007 - Elsevier
The increasing threat of nerve agent use for terrorist purposes against civilian and military
population calls for effective therapeutic preparedness. At present, administration of atropine …

The acute treatment of nerve agent exposure

K Cannard - Journal of the neurological sciences, 2006 - Elsevier
Nerve agents (NA) are simple and cheap to produce but can produce casualties on a
massive scale. They have already been employed by terrorist organizations and rogue …

The pharmacology, toxicology, and medical treatment of sulphur mustard poisoning

M Balali‐Mood, M Hefazi - Fundamental & clinical …, 2005 - Wiley Online Library
Sulphur mustard (SM) is regarded as one of the most important agents of chemical warfare
because of its simple and cheap chemical synthesis that makes it readily available for both …

Prehospital management of sarin nerve gas terrorism in urban settings: 10 years of progress after the Tokyo subway sarin attack

Y Tokuda, M Kikuchi, O Takahashi, GH Stein - Resuscitation, 2006 - Elsevier
Chemical agents have been used previously in wartime on numerous occasions, from World
War I to the Gulf War. In 1994 and1995, sarin nerve gas was used first in peacetime as a …

Pathophysiological and clinical aspects of combat anticholinesterase poisoning

AA Weinbroum - British Medical Bulletin, 2004 - academic.oup.com
Nerve agents are organophosphate compounds similar to those used as pesticides but with
much higher toxicity. They all block the activity of the enzyme acetylcholine esterase. Victims …