Andrographolide Inhibits Inflammatory Cytokines Secretion in LPS‐Stimulated RAW264.7 Cells through Suppression of NF‐κB/MAPK Signaling Pathway

Y Li, S He, J Tang, N Ding, X Chu… - Evidence‐Based …, 2017 - Wiley Online Library
Andrographolide, the main active component extracted from Andrographis paniculata (Burm.
f.) Wall. ex Nees, exerts anti‐inflammatory effects; however, the principal molecular …

Andrographolide acts as an anti-inflammatory agent in LPS-stimulated RAW264. 7 macrophages by inhibiting STAT3-mediated suppression of the NF-κB pathway

KC Lee, HH Chang, YH Chung, TY Lee - Journal of ethnopharmacology, 2011 - Elsevier
Ethnopharmacological significance Inflammation is involved in numerous diseases, such as
chronic inflammatory disease and cancer. Many plant products exhibit useful biological …

AP‐1/IRF‐3 Targeted Anti‐Inflammatory Activity of Andrographolide Isolated from Andrographis paniculata

T Shen, WS Yang, YS Yi, GH Sung… - Evidence‐Based …, 2013 - Wiley Online Library
Andrographolide (AG) is an abundant component of plants of the genus Andrographis and
has a number of beneficial properties including neuroprotective, anticancer, anti …

[HTML][HTML] Andrographolide inhibits inflammatory responses in LPS-stimulated macrophages and murine acute colitis through activating AMPK

N Kim, P Lertnimitphun, Y Jiang, H Tan, H Zhou… - Biochemical …, 2019 - Elsevier
Abstract Andrographolide (Andro), a well-known labdane diterpenoid of Andrographis
paniculata, has been reported to have anti-inflammatory effects in various inflammatory …

Inhibitory effects of andrographolide on activated macrophages and adjuvant-induced arthritis

S Gupta, KP Mishra, SB Singh, L Ganju - Inflammopharmacology, 2018 - Springer
Andrographolide, a diterpenoid lactone obtained from plant Andrographis paniculata, is
used in South Asian countries to relieve various inflammatory symptoms. To study the effects …

Inhibition of TNF-α-Induced Inflammation by andrographolide via down-regulation of the PI3K/Akt signaling pathway

HW Chen, AH Lin, HC Chu, CC Li… - Journal of natural …, 2011 - ACS Publications
Andrographolide (1), an active constituent of Andrographis paniculata, decreased tumor
necrosis factor-α (TNF-α)-induced intercellular adhesion molecule-1 (ICAM-1) expression …

Suppression of matrix metalloproteinase-9 expression by andrographolide in human monocytic THP-1 cells via inhibition of NF-κB activation

WR Lee, CL Chung, CJ Hsiao, YC Chou, PJ Hsueh… - Phytomedicine, 2012 - Elsevier
There is much evidence indicating that human leukemic cells and monocytes/macrophages
synthesize, and secrete, several matrix metalloproteinases (MMPs), and participate in the …

Andrograpanin, isolated from Andrographis paniculata, exhibits anti-inflammatory property in lipopolysaccharide-induced macrophage cells through down-regulating …

J Liu, ZT Wang, BX Ge - International immunopharmacology, 2008 - Elsevier
Andrographis paniculata Nees is an official herbal medicine for treatment of infection and
inflammation in China. Andrograpanin, the one of diterpene lactones in A. paniculata, is a …

Water-soluble andrographolide sulfonate exerts anti-sepsis action in mice through down-regulating p38 MAPK, STAT3 and NF-κB pathways

W Guo, W Liu, G Chen, S Hong, C Qian, N Xie… - International …, 2012 - Elsevier
Andrographolide is a prescribed drug used for preventing and treating the common cold,
influenza, viral infections or allergies. However, its poor water solubility enormously limits its …

[HTML][HTML] Andrographolide ameliorates d-galactosamine/lipopolysaccharide-induced acute liver injury by activating Nrf2 signaling pathway

C Pan, S Yang, Z Pan, B Zheng, J Wang, G Lu, Z Xue… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Andrographolide (ADH), a diterpenoid lactone extracted from Andrographis paniculata, has
been found to have anti-inflammatory and anti-oxidative effects. However, its protective …