Making sense of hematopoietic stem cell niches

PE Boulais, PS Frenette - Blood, The Journal of the American …, 2015 - ashpublications.org
The hematopoietic stem cell (HSC) niche commonly refers to the pairing of hematopoietic
and mesenchymal cell populations that regulate HSC self-renewal, differentiation, and …

Adult haematopoietic stem cell niches

GM Crane, E Jeffery, SJ Morrison - Nature Reviews Immunology, 2017 - nature.com
Stem cell niches are specialized microenvironments that promote the maintenance of stem
cells and regulate their function. Recent advances have improved our understanding of the …

Complexity of bone marrow hematopoietic stem cell niche

N Asada, S Takeishi, PS Frenette - International journal of hematology, 2017 - Springer
Hematopoietic stem cells (HSCs) that produce a variety of hematopoietic lineage cells
throughout the life reside in specialized microenvironment called “niche” in the bone marrow …

[HTML][HTML] The evolving view of the hematopoietic stem cell niche

I Beerman, TC Luis, S Singbrant, CL Celso… - Experimental …, 2017 - Elsevier
Highlights•The hematopoietic stem cell niche is a dynamic and complex environment.•
Summary of a webinar lead and moderated by experts of this topic.Hematopoietic stem cells …

Niche-to-niche migration of bone-marrow-derived cells

RN Kaplan, B Psaila, D Lyden - Trends in molecular medicine, 2007 - cell.com
During ontogenesis, haematopoietic stem cells (HSCs) relocate between extra-embryonic
and embryonic compartments. Similarly, site-specific homing of HSCs is ongoing during …

[HTML][HTML] The hematopoietic stem cell niche

D Park, DB Sykes, DT Scadden - Frontiers in bioscience (Landmark …, 2012 - ncbi.nlm.nih.gov
Hematopoietic stem cells (HSCs) possess the ability to self-renew and to differentiate to
mature progeny along multiple different hematopoietic lineages. The function of HSCs …

Dynamic niches in the origination and differentiation of haematopoietic stem cells

LD Wang, AJ Wagers - Nature reviews Molecular cell biology, 2011 - nature.com
Haematopoietic stem cells (HSCs) are multipotent, self-renewing progenitors that generate
all mature blood cells. HSC function is tightly controlled to maintain haematopoietic …

Haematopoietic stem cell activity and interactions with the niche

S Pinho, PS Frenette - Nature reviews Molecular cell biology, 2019 - nature.com
The haematopoietic stem cell (HSC) microenvironment in the bone marrow, termed the
niche, ensures haematopoietic homeostasis by controlling the proliferation, self-renewal …

The vascular niche: home for normal and malignant hematopoietic stem cells

PL Doan, JP Chute - Leukemia, 2012 - nature.com
Hematopoietic stem cells (HSCs) are uniquely capable of self-renewal and provision of all of
the mature elements of the blood and immune system throughout the lifetime of an …

Uncertainty in the niches that maintain haematopoietic stem cells

MJ Kiel, SJ Morrison - Nature Reviews Immunology, 2008 - nature.com
Haematopoietic stem cell (HSC) niches are specialized microenvironments that contain
stem cells and regulate their maintenance. Cells at the interface of bone and the bone …