Many people around the world suffer from some form of paralysis caused by spinal cord
injury (SCI), which has an impact on quality and life expectancy. The spinal cord is part of …

Traumatic injury to the mammalian spinal cord is a highly dynamic process characterized by
a complex pattern of pervasive and destructive biochemical and pathophysiological events …

The mitochondrion is a double membrane structured organelle involved in a variety of
regulatory functions such as calcium signaling, production of adenosine triphosphate …

Spinal cord injury (SCI) is characterized by an initial trauma followed by a progressive
cascade of damage referred to as secondary injury. A hallmark of secondary injury is …

Mitochondria are organelles responsible for bioenergetic metabolism, calcium homeostasis,
and signal transmission essential for neurons due to their high energy consumption …

Axonal degeneration is a major contributor to neuronal dysfunction in many neurological
conditions and has additional roles in development. It can be triggered by divergent stimuli …

Mitochondrial dysfunction is a hallmark of secondary neuroinflammatory responses and
neuronal death in spinal cord injury (SCI). Even though mitochondria-based therapy is an …

Each year, traumatic brain injury (TBI) causes a high rate of mortality throughout the world
and those who survive have lasting disabilities. Given that the brain is a particularly dynamic …

Over the last decade, mitochondrial dynamics beyond function during axon regeneration/
degeneration have received attention. Axons have an effective delivery system of …

In recent years, multiple disciplines have focused on mitochondrial biology and contributed
to understanding its relevance towards adult-onset neurodegenerative disorders. These are …