Weak ergodicity breaking of receptor motion in living cells stemming from random diffusivity

C Manzo, JA Torreno-Pina, P Massignan… - Physical Review X, 2015 - APS
Molecular transport in living systems regulates numerous processes underlying biological
function. Although many cellular components exhibit anomalous diffusion, only recently has …

Intracellular transport by active diffusion

CP Brangwynne, GH Koenderink, FC MacKintosh… - Trends in cell …, 2009 - cell.com
All substances exhibit constant random motion at the microscopic scale. This is a direct
consequence of thermal agitation, and leads to diffusion of molecules and small particles in …

Ergodic and nonergodic processes coexist in the plasma membrane as observed by single-molecule tracking

AV Weigel, B Simon, MM Tamkun… - Proceedings of the …, 2011 - National Acad Sciences
Diffusion in the plasma membrane of living cells is often found to display anomalous
dynamics. However, the mechanism underlying this diffusion pattern remains highly …

[HTML][HTML] Single-particle diffusion characterization by deep learning

N Granik, LE Weiss, E Nehme, M Levin, M Chein… - Biophysical journal, 2019 - cell.com
Diffusion plays a crucial role in many biological processes including signaling, cellular
organization, transport mechanisms, and more. Direct observation of molecular movement …

[HTML][HTML] Sampling the cell with anomalous diffusion—the discovery of slowness

G Guigas, M Weiss - Biophysical journal, 2008 - cell.com
Diffusion-mediated searching for interaction partners is an ubiquitous process in cell
biology. Transcription factors, for example, search specific DNA sequences, signaling …

Anomalous diffusion due to hindering by mobile obstacles undergoing Brownian motion or Orstein-Ulhenbeck processes

H Berry, H Chaté - Physical Review E, 2014 - APS
In vivo measurements of the passive movements of biomolecules or vesicles in cells
consistently report “anomalous diffusion,” where mean-squared displacements scale as a …

[HTML][HTML] Ergodicity breaking on the neuronal surface emerges from random switching between diffusive states

A Weron, K Burnecki, EJ Akin, L Solé, M Balcerek… - Scientific reports, 2017 - nature.com
Stochastic motion on the surface of living cells is critical to promote molecular encounters
that are necessary for multiple cellular processes. Often the complexity of the cell …

Stochastic nonlinear dynamics of confined cell migration in two-state systems

DB Brückner, A Fink, C Schreiber, PJF Röttgermann… - Nature Physics, 2019 - nature.com
Migrating cells in physiological processes, including development, homeostasis and cancer,
encounter structured environments and are forced to overcome physical obstacles. Yet, the …

Constrained diffusion or immobile fraction on cell surfaces: a new interpretation

TJ Feder, I Brust-Mascher, JP Slattery, B Baird… - Biophysical journal, 1996 - cell.com
Protein lateral mobility in cell membranes is generally measured using fluorescence
photobleaching recovery (FPR). Since the development of this technique, the data have …

Development of anomalous diffusion among crowding proteins

MR Horton, F Höfling, JO Rädler, T Franosch - Soft Matter, 2010 - pubs.rsc.org
In cell membranes, proteins and lipids diffuse in a highly crowded and heterogeneous
landscape, where aggregates and dense domains of proteins or lipids obstruct the path of …