Type 1 diabetes results from a genetically and immunologically complex autoimmune
process that is specifically directed against the pancreatic beta cells. Non-obese diabetic …

Type 1 diabetes is an immune-mediated disease in which pancreatic insulin-producing beta
cells are damaged and destroyed. Animal models have served a prominent function in the …

T1DM (Type I diabetes mellitus) results from selective destruction of the insulin-producing β-
cells of the pancreas by the immune system, and is characterized by hyperglycaemia and …

The spontaneous autoimmune diabetes of the nonobese diabetic mouse and the
BioBreeding diabetes-prone rat bears a striking similarity to human type 1 diabetes. For this …

We can now predict the development of type 1A diabetes in humans and prevent the
disorder in animal models, but we cannot at present safely prevent type 1A diabetes in …

Transgenic mouse technology has gained recognition as an important tool for examining
many fundamental biological questions in vivo. Recently, transgenic mouse techniques …

Despite decades of studying rodent models of type 1 diabetes (T1D), no therapy capable of
preventing or curing T1D has successfully been translated from rodents to humans. This …

Type 1 diabetes mellitus (T1DM) is an autoimmune disease arising through a complex
interaction of both genetic and immunologic factors. Similar to the majority of autoimmune …

Non-obese diabetic (NOD) mice are an excellent model of T-cell mediated autoimmune
insulin-dependent diabetes in humans. Recent studies in NOD mice have shown that this …

The nonobese diabetic (NOD) mouse represents probably the best spontaneous model for a
human autoimmune disease. It has provided not only essential information on type 1 …