Alterations in epigenetic gene regulation are associated with human disease. Here, we
discuss connections between DNA methylation and histone methylation, providing …

Knowledge on heritable changes in gene expression that result from epigenetic events is of
increasing relevance in the development of strategies for prevention, early diagnosis and …

Epigenetic gene inactivation in transformed cells involves many 'belts of silencing'. One of
the best-known lesions of the malignant cell is the transcriptional repression of tumor …

DNA methylation is a heritable and stable epigenetic mark associated with transcriptional
repression. Changes in the patterns and levels of global and regional DNA methylation …

The phenotype of the cancerous cell may arise either from genetic alterations that disrupt
gene function through sequence modifications (mutations) or epigenetic events that may …

Background Previous studies of individual genes have shown that in a self-enforcing way,
dimethylation at histone 3 lysine 9 (dimethyl-H3K9) and DNA methylation cooperate to …

Recently, the concept that epigenetic, as well as genetic, events might be central to the
evolution of human cancer is re-emerging. Cancers often exhibit an aberrant methylation of …

Epigenetic modifications of cytosine residues in DNA and the amino termini of histone
proteins have emerged as key mechanisms in chromatin remodeling, impacting both the …

The discovery of numerous hypermethylated promoters of tumour–suppressor genes, along
with a better understanding of gene–silencing mechanisms, has moved DNA methylation …

Epigenetic silencing in cancer cells is mediated by at least two distinct histone modifications,
polycomb-based histone H3 lysine 27 trimethylation (H3K27triM) and H3K9 dimethylation …