The α2A-adrenergic receptor (AR) subtype mediates antinociception induced by the α2AR
agonists clonidine, dexmedetomidine, norepinephrine, and 5-bromo-N-(4, 5-dihydro-1 H …

α2-Adrenergic receptor (AR)-selective compounds produce antihypertensive and
antinociceptive effects. Moxonidine alleviates hypertension in multiple species, including …

Agonists acting at α2 adrenergic and opioid receptors have analgesic properties and act
synergistically when co-administered in the spinal cord; this synergy may also contribute to …

adrenergic transmitter (norepinephrine), serotonin; cholinergic transmitter (acetylcholine);
inhibitory (γ-aminobutyric acid) and excitatory (glutamate) amino acids; opioid and …

This study was designed primarily to relate the antinociceptive and hemodynamic effects of
clinically available α 2-adrenoceptor agonists to their binding affinity for α 2-adrenoceptors …

Endogenous, descending noradrenergic fibers impose analgesic control over spinal afferent
circuitry mediating the rostrad transmission of pain signals. These fibers target alpha 2 …

The interaction between the spinal antinociceptive effects of selective μ or δ opioid agonists
morphine and DSTBULET (Tyr-d-Ser (OtBu)-Gly-Phe-Leu-Thr), respectively, and the …

This study was undertaken to evaluate the antinociceptive interactions of [alpha] 2
adrenergic and opiate receptors at tin spinal level. Morphine and clonidine were …

We have previously shown that norepinephrine can produce hyperalgesia via an α2-
adrenergic receptor mechanism. The α2-adrenergic receptor agonist clonidine has …

Descending noradrenergic pathways contribute to feedback inhibition of pain by releasing
norepinephrine in the spinal cord. Noradrenergic nuclei in the pons contain abundant α2 …