Desethylamiodarone (DA) is a major metabolite of amiodarone (AM), a Class III
antiarrhythmic drug. The plasma pharmacokinetics and tissue distribution of AM and DA (10 …

Patients who receive amiodarone may develop interstitial pulmonary disease. The objective
of the present study was to develop an experimental model of interstitial pulmonary disease …

Background: Amiodarone is a potent antiarrhythmic agent that is limited in clinical use by its
adverse effects, including potentially life threatening amiodarone-induced pulmonary toxicity …

Background and Purpose The aim of the present study was to study the antiarrhythmic
effects and cellular mechanisms of desethylamiodarone (DEA), the main metabolite of …

Amiodarone is a widely used potent antiarrhythmic for the treatment of cardiac disease;
however, its use is often discontinued due to numerous adverse effects, including …

A liquid chromatographic‐mass spectrometry (LC/MS) assay method was developed for the
determination of amiodarone and desethylamiodarone in rat specimens. Analytes were …

HYDROCHLORIDE, a benzofurone derivative, has been used since 1969 for the control of
cardiac arrhythmias in the United States. It appears to be uniquely effective for some patients …

As damage to the pulmonary vascular endothelium may be responsible for the lung toxicity
of amiodarone, we evaluated the cytolytic toxicity of the drug in cultures of endothelial cells …

Amiodarone (AMD) is one of the most effective antiarrhythmic drugs available. However, its
use is often limited by side-effects, mainly hypo-or hyperthyroidism. As AMD displays direct …

Amiodarone (AM) is a potent antidysrhythmic agent that is limited in clinical use by its
adverse effects, including potentially life-threatening AM-induced pulmonary toxicity (AIPT) …