A series of novel 6-fluorochroman derivatives was prepared and evaluated as antagonists
for the 5-HT1A receptor. N-2-[[(6-Fluorochroman-8-yl) oxy] ethyl]-4-(4-methoxyphenyl) …

A series of benzamides was synthesized as selective agonists for the 5-HT1A receptor. It
was found that (S)-N-{[1-(2-phenylethyl) pyrrolidin-2-yl] methyl} cyclohexanecarboxamide (7 …

A series of N-[2-[(substituted chroman-8-yl) oxy] ethyl]-4-(4-methoxyphenyl) butylamines was
prepared and examined for their 5-HT1A receptor antagonist activity. The parent compound …

The aim of this work was to improve the oral bioavailability of a recently discovered, novel
structural class of 5-HT1A receptor agonists: aryl-{[4-(6-R-pyridin-2-ylmethyl)-amino]-methyl} …

New substituted benzamides as SHT, receptor antagonists Page 1 Eur J Med Chem (1995)
30,65 l-654 0 Elsevier, Paris 651 Short communication New substituted benzamides as SHT …

A major focus of our research for a number of years has been to understand the structure-
activity relationship (SAR) of classical hallucinogens and their derivatives, the …

Structural modification of the 2-methoxy group and at the 4-position of the piperidine ring of
the 5-HT 4 partial agonist 1 led to analogues with increased affinity for the 5-HT 4 receptor …

Starting from compounds previously identified as α1-adrenoceptor antagonists that were
also found to bind to the 5-HT1A receptor, in an attempt to separate the two activities, a new …

Alzheimer's disease (AD) is a neurodegenerative disorder that has a higher prevalence and
incidence in people older than 60 years. The need for improved AD therapies is unmet as …

It is thought that selective 5-HT4 receptor agonists—such as 4-amino-5-chloro-2-methoxy-N-
[1-(6-oxo-6-phenylhexyl) piperidin-4-ylmethyl] benzamide (2)—have the ability to enhance …