Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels tumour heterogeneity plus M2-like tumour-associated macrophage infiltration and …
Triple-negative breast cancer (TNBC) is characterized by a more aggressive clinical course
with extensive inter-and intra-tumour heterogeneity. Combination of single-cell and bulk …
with extensive inter-and intra-tumour heterogeneity. Combination of single-cell and bulk …
Unravelling subclonal heterogeneity and aggressive disease states in TNBC through single-cell RNA-seq
Triple-negative breast cancer (TNBC) is an aggressive subtype characterized by extensive
intratumoral heterogeneity. To investigate the underlying biology, we conducted single-cell …
intratumoral heterogeneity. To investigate the underlying biology, we conducted single-cell …
Integrated analysis of single-cell RNA-seq and bulk RNA-seq unravels T cell-related prognostic risk model and tumor immune microenvironment modulation in triple …
S Guo, X Liu, J Zhang, Z Huang, P Ye, J Shi… - Computers in biology …, 2023 - Elsevier
Background Triple negative breast cancer (TNBC) is an aggressive and fatal malignancy.
The current success of tumor immunotherapy has focused attention on intermediate T-cell …
The current success of tumor immunotherapy has focused attention on intermediate T-cell …
[PDF][PDF] Unraveling triple-negative breast cancer tumor microenvironment heterogeneity: towards an optimized treatment approach
Background Recent efforts of gene expression profiling analyses recognized at least four
different triple-negative breast cancer (TNBC) molecular subtypes. However, little is known …
different triple-negative breast cancer (TNBC) molecular subtypes. However, little is known …
Multi-omics profiling reveals distinct microenvironment characterization and suggests immune escape mechanisms of triple-negative breast cancer
Y Xiao, D Ma, S Zhao, C Suo, J Shi, MZ Xue… - Clinical cancer …, 2019 - AACR
Purpose: The tumor microenvironment has a profound impact on prognosis and
immunotherapy. However, the landscape of the triple-negative breast cancer (TNBC) …
immunotherapy. However, the landscape of the triple-negative breast cancer (TNBC) …
Single-cell RNA-seq dissects the intratumoral heterogeneity of triple-negative breast cancer based on gene regulatory networks
S Zhou, Y Huang, H Liu, X Zhou, M Yuan, F Hou… - … Therapy-Nucleic Acids, 2021 - cell.com
Triple-negative breast cancer (TNBC) is a subtype of breast cancer with high intratumoral
heterogeneity. Recent studies revealed that TNBC patients might comprise cells with distinct …
heterogeneity. Recent studies revealed that TNBC patients might comprise cells with distinct …
M2-like tumor-associated macrophage-related biomarkers to construct a novel prognostic signature, reveal the immune landscape, and screen drugs in hepatocellular …
X Qu, X Zhao, K Lin, N Wang, X Li, S Li… - Frontiers in …, 2022 - frontiersin.org
Background M2-like tumor-associated macrophages (M2-like TAMs) have important roles in
the progression and therapeutics of cancers. We aimed to detect novel M2-like TAM-related …
the progression and therapeutics of cancers. We aimed to detect novel M2-like TAM-related …
Stromal cell diversity associated with immune evasion in human triple‐negative breast cancer
The tumour stroma regulates nearly all stages of carcinogenesis. Stromal heterogeneity in
human triple‐negative breast cancers (TNBCs) remains poorly understood, limiting the …
human triple‐negative breast cancers (TNBCs) remains poorly understood, limiting the …
High densities of tumor-associated plasma cells predict improved prognosis in triple negative breast cancer
Breast cancer is the most common malignancy affecting women, but the heterogeneity of the
condition is a significant obstacle to effective treatment. Triple negative breast cancers …
condition is a significant obstacle to effective treatment. Triple negative breast cancers …
Association between genomic metrics and immune infiltration in triple-negative breast cancer
Importance Why some triple-negative breast cancers (TNBCs) have high and others have
low immune cell infiltration is unknown. Understanding how immune surveillance shapes …
low immune cell infiltration is unknown. Understanding how immune surveillance shapes …