Abdominal Aortic Aneurysm (AAA) affects 4–5% of men over 65, and Aortic Dissection (AD)
is a life-threatening aortic pathology associated with high morbidity and mortality. Initiators of …

Recent basic and clinical research has established a link between the pathogenesis of
abdominal aortic aneurysms (AAA) and matrix metalloproteinases (MMP). The discovery of …

Background: Aortic abdominal aneurysm (AAA) represents a common chronic degenerative
disease of the aortic wall. Chronic inflammation and enzymatic degradation of elastic …

BACKGROUND:: The increased synthesis of matrix metalloproteinases (MMPs) by aortic
smooth muscle cells (SMCs) is thought to be involved in the etiopathogenesis of abdominal …

Thoracic aortic dissection, one of the major diseases affecting the aorta, carries a very high
mortality rate. Improving our understanding of the pathobiology of this disease may help us …

Abdominal aortic aneurysm (AAA) is a significant health problem in the United States, with
approximately 30,000 repair operations annually. Treatment of AAA is associated with more …

Background Although abdominal aortic aneurysms (AAAs) exhibit increased expression of
matrix metalloproteinases (MMPs), the functional balance between MMPs and their tissue …

BACKGROUND: The role of matrix metalloproteinases (MMPs) in abdominal aortic
aneurysm (AAA) formation is well established. However the changes in plasma MMP levels …

Degradation of extracellular matrix, especially elastin, within the aortic wall is a hallmark of
abdominal aortic aneurysms (AAAs). Normal turnover of matrix proteins is mediated by a …

Background—Abdominal aortic aneurysm (AAA) expansion is characterized by extracellular
matrix degradation and widespread inflammation. In contrast, the processes that …