T cells specific for a single viral epitope, but using different T cell receptors, should have
flexibility in their epitope recognition to protect the infected host against the emergence of …

We investigated the specific and cross-reactive CD8 T cell immunity to three natural variants
(of different geno/serotype) of the small hepatitis B surface Ag (or S protein). The D d-binding …

Distinct populations of hepatocytes infected with hepatitis B virus (HBV) or only harboring
HBV DNA integrations coexist within an HBV chronically infected liver. These hepatocytes …

We have recently developed the technology to identify and characterize the human
histocompatibility leukocyte antigen (HLA) class I-restricted, CD8+ cytotoxic T lymphocyte …

The cytotoxic T-cell response in chronic hepatitis B virus (HBV) infection has been described
as weak and mono-or oligospecific in comparison to the more robust virus-specific T-cell …

The adaptive immune response, particularly the virus‐specific CD8+ T‐cell response, is
largely responsible for viral clearance and disease pathogenesis during hepatitis B virus …

In this review we focus on aspects of the virus‐specific cellular immune response, although
we should point out that all the components of the innate and adaptive immune response …

Background & Aims: Cytotoxic T cells have been suggested to be responsible for lysis of
hepatitis B virus (HBV)-infected hepatocytes and control of virus infection. The frequency …

Mutations that abrogate recognition of a viral epitope by class I-restricted cytotoxic T
lymphocyte (CTL) can lead to viral escape if the CTL response against that epitope is crucial …

Deletion, anergy, and a spectrum of functional impairments can affect virus-specific CD8
cells in chronic viral infections. Here we characterize a low frequency population of CD8 …