Retinoblastoma-binding protein (RBBP) family is a class of proteins that can interact with
tumor suppressor retinoblastoma protein (pRb). RBBP4 and RBBP7 are the only pair of …

Regulators of the tumour suppressor protein, p53 are promising anti-cancer drug
candidates. The retinoblastoma binding protein 6 (RBBP6), a p53 negative regulator, has …

RBBP4 is a nuclear WD40 motif-containing protein widely implicated in various cancers and
a putative drug target. It interacts with multiple proteins within diverse complexes such as …

Simple Summary Rb1 is a regulator of cell cycle progression and genomic stability. This
review focuses on post-translational modifications, their effect on Rb1 interactors, and their …

The retinoblastoma protein or its regulators are altered in most human cancers. Although
commonly thought of as solely a repressor of E2F-dependent transcription and cell cycle …

RBBP6 is a 250 kDa eukaryotic protein known to be a negative regulator of p53 and
essential for embryonic development. Furthermore, RBBP6 is a critical element in …

Abstract Retinoblastoma-binding protein 1 (RBBP1) is involved in gene regulation,
epigenetic regulation, and disease processes. RBBP1 contains five domains with DNA …

The retinoblastoma (RB) family consists of three genes, RB1, RBL1, and RBL2, that code for
the pRb, p107, and pRb2/p130 proteins, respectively. All these factors have pivotal roles in …

The retinoblastoma (Rb) gene was identified as the first tumor suppressor gene two decades
ago. Since this initial discovery, it has become clear that deregulated Rb function constitutes …

RB family members are negative regulators of the cell cycle, involved in numerous biological
processes such as cellular senescence, development and differentiation. Disruption of RB …