Total synthesis of levetiracetam, an active ingredient of epilepsy treatment medications, is
reported. The reported method is based on a one-pot dehydration/sigmatropic …

An alternate synthesis of enantiomerically pure levetiracetam (Keppra®) - ScienceDirect Skip
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An asymmetric synthesis of (S)-levetiracetam has been developed through application of a
Strecker reaction using [(1S)-1-(4-methoxyphenyl) ethyl] amine hydrochloride as a chiral …

We report an asymmetric synthesis of (‐)‐Levetiracetam (1) in six steps starting from
versatile new chiral N‐sulfinimine (3). The key step, stereoselective 1, 2‐addition of …

The synthesis of levetiracetam and its enantiomer by deracemization of (±)-2-bromobutyric
acid using either (S)-or (R)-N-phenylpantolactam as chiral auxiliaries, followed by SN2 …

A simple route to enantiomerically pure (S)-2-aminobutyramide–the chiral component of the
anti-epileptic drugs Levetiracetam and Brivaracetam has been developed. This approach is …

A practical and efficient enantioselective synthesis of antiepileptic drug,(−)‐Levetiracetam,
has been described in five steps (33.0% overall yield) and high optical purity (99.0% ee) …

Levetiracetam,[(S)-1](Keppra®, 38), was approved by the FDA, at the end of 1999 as an
antiepileptic drug for an add-on therapy for partial onset seizures in adults with epilepsy …

A chemoenzymatic approach for the synthesis of α-N-heterocyclic ethyl-and
phenylacetamides, levetiracetam analogs, is described. Eight nitrile substrates were …

A short enantioselective synthesis of the antiepileptic agent, levetiracetam based on proline-catalyzed
asymmetric α-aminooxylation - ScienceDirect Skip to main contentSkip to article Elsevier …