Th17/IL-17 Axis in HTLV-1-associated myelopathy tropical spastic Paraparesis and multiple sclerosis: novel insights into the immunity during HAMTSP

M Shafiei, SH Mozhgani - Molecular Neurobiology, 2023 - Springer
Human T lymphotropic virus–associated myelopathy/tropical spastic paraparesis
(HTLV/TSP), also known as HTLV-associated myelopathy/tropical spastic paraparesis …

How does interleukin 15 contribute to the pathogenesis of HTLV type 1-associated myelopathy/tropical spastic paraparesis?

N Azimi, J Mariner, S Jacobson… - AIDS research and …, 2000 - liebertpub.com
HTLV-1 is the etiological agent of a neurological disease named HAM/TSP that has clinical
characteristics similar to those of multiple sclerosis (MS). The PBMC obtained from …

CD80+ and CD86+B cells as biomarkers and possible therapeutic targets in HTLV-1 associated myelopathy/tropical spastic paraparesis and multiple sclerosis

SM Menezes, D Decanine, D Brassat, R Khouri… - Journal of …, 2014 - Springer
Background Human T-cell lymphotropic virus (HTLV-1) is the causative agent of the
incapacitating, neuroinflammatory disease HTLV-1-associated myelopathy/tropical spastic …

Role of IL-21 in HTLV-1 infections with emphasis on HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)

T Rajaei, H Farajifard, H Rafatpanah, R Bustani… - Medical microbiology …, 2017 - Springer
Abstract Interleukin-21 (IL-21) enhances the survival and cytotoxic properties of cytotoxic T
cells (CTLs) and exhibits essential roles in controlling chronic viral infections. HTLV-1 …

CD49d is upregulated in circulating T lymphocytes from HTLV-1-infected patients

LT Janahú, CA Da Costa, ACR Vallinoto… - …, 2021 - karger.com
Abstract Introduction: HTLV-1-associated myelopathy/tropical spastic paraparesis
(HAM/TSP) is a chronic progressive myelopathy associated with an inflammation of the …

Immunovirological markers in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP)

Y Enose-Akahata, S Jacobson - Retrovirology, 2019 - Springer
Human T cell lymphotropic virus 1 (HTLV-1) is a human retrovirus and infects approximately
10–20 million people worldwide. While the majority of infected people are asymptomatic …

Up-regulation of interleukin-12 receptor expression in peripheral blood mononuclear cells of patients with HTLV-I-associated myelopathy/tropical spastic paraparesis

T Fujimoto, T Nakamura, Y Nishiura, K Ichinose… - Journal of the …, 2002 - Elsevier
We previously reported elevated levels of serum interleukin-12 (IL-12) in association with
increased interferon-γ (IFN-γ) levels in patients with human T-lymphotropic virus type I …

HTLV-1 induces a Th1-like state in CD4+ CCR4+ T cells that produces an inflammatory positive feedback loop via astrocytes in HAM/TSP

Y Yamano, A Coler-Reilly - Journal of neuroimmunology, 2017 - Elsevier
The main feature of Human T-lymphotropic virus type I (HTLV-1)-associated
myelopathy/tropical spastic paraparesis (HAM/TSP) pathogenesis is a virus-induced …

Expansion in CD39+ CD4+ Immunoregulatory T Cells and Rarity of Th17 Cells in HTLV-1 Infected Patients Is Associated with Neurological Complications

FE Leal, LC Ndhlovu, AM Hasenkrug… - PLoS neglected …, 2013 - journals.plos.org
HTLV-1 infection is associated with several inflammatory disorders, including the
neurodegenerative condition HTLV-1-associated myelopathy/tropical spastic paraparesis …

HAM/TSP-derived HTLV-1-infected T cell lines promote morphological and functional changes in human astrocytes cell lines: possible role in the enhanced T cells …

ES Gudo, SD Silva-Barbosa, L Linhares-Lacerda… - Virology Journal, 2015 - Springer
Background The mechanisms through which HTLV-1 leads to and maintains damage in the
central nervous system of patients undergoing HTLV-1 associated myelopathy/tropical …