The generation of properly functioning gametes in vitro requires reconstitution of the
multistepped pathway of germ cell development. We demonstrate here the generation of …

Mechanisms underlying human germ cell development are unclear, partly due to difficulties
in studying human embryos and lack of suitable experimental systems. Here, we show that …

Mammalian male germ-cell development consists of three distinct phases: primordial germ
cell (PGC) development, male germ-cell specification for spermatogonium development …

Germ cell development creates totipotency through genetic as well as epigenetic regulation
of the genome function. Primordial germ cells (PGCs) are the first germ cell population …

Pluripotent epiblast stem cells (EpiSCs) derived from postimplantation embryos exhibit
properties that are characteristically different when compared with pluripotent embryonic …

Germ cells are unique cell types that generate a totipotent zygote upon fertilization, giving
rise to the next generation in mammals and many other multicellular organisms. How germ …

Primordial germ cells (PGCs) are derived from a population of pluripotent epiblast cells in
mice. However, little is known about when and how PGCs acquire the capacity to …

The germ cell lineage originates early in development and undergoes a series of complex
developmental processes that culminate in the generation of fully matured gametes, the …

Spermatogonial stem cells (SSCs) maintain spermatogenesis by self-renewal and
generation of spermatogonia committed to differentiation. Under certain in vitro conditions …

Germline specification underlies human reproduction and evolution, but it has proven
difficult to study in humans since it occurs shortly after blastocyst implantation. This process …