We have examined the relative methylation levels of several dispersed repeated and low-
copy-number gene sequences during gametogenesis and early embryogenesis. Southern …

Methylation patterns of specific genes have been studied by polymerase chain reaction and
found to undergo dynamic changes in the germ line and early embryo. Some CpG sites are …

The transgenic sequences in the mouse line TKZ751 are demethylated on a DBA/2 inbred
strain background but become highly methylated at postimplantation stages in offspring of a …

Several lines of evidence strongly suggest that DNA methylation is involved in embryo
development. Perhaps the most direct evidence comes from experiments with …

Publisher Summary This chapter discusses the deoxyribonucleic acid (DNA) methylation
from embryo to adult. The existence of tissue-specific methylation patterns and the results of …

In mammals, the maternal and the paternal genome are not functionally equivalent and are
both required for embryonic and postnatal development. The genome is organised …

Changing DNA methylation patterns during embryonic development are discussed in
relation to differential gene expression, changes in X-chromosome activity and genomic …

ABSTRACT A number of transgenes in the mouse show variation in methylation and
expression phenotypes dependent on parental transmission. It appears that there exist at …

Biermann and Steger N Epigenetics in Male Germ Cells 467 fertility; as in Dnmt3L2/2 mice,
pachytene spermatocytes exhibit homologous chromosomes that fail to align and form …

DNA methylation differences between maternal and paternal alleles of many imprinted
genes are inherited from the male and female gametes and subsequently maintained during …