[HTML][HTML] Semaglutide effects on cardiovascular outcomes in people with overweight or obesity (SELECT) rationale and design

DH Ryan, I Lingvay, HM Colhoun, J Deanfield… - American heart …, 2020 - Elsevier
Cardiovascular disease (CVD) is a major cause of morbidity and mortality. Although it has
been widely appreciated that obesity is a major risk factor for CVD, treatments that produce …

Semaglutide for cardiovascular event reduction in people with overweight or obesity: SELECT study baseline characteristics

I Lingvay, K Brown‐Frandsen, HM Colhoun… - …, 2023 - Wiley Online Library
Objective This paper describes the baseline characteristics of the Semaglutide Effects on
Heart Disease and Stroke in Patients with Overweight or Obesity (SELECT) study, one of the …

Obesity, cardiovascular disease, and the promising role of semaglutide: insights from the SELECT trial

H Irfan - Current Problems in Cardiology, 2024 - Elsevier
Cardiovascular disease (CVD) is a leading global cause of death, with preventable risk
factors like obesity contributing most to it. Obesity's association with CVD originate from …

[HTML][HTML] Semaglutide and cardiovascular outcomes in obesity without diabetes

AM Lincoff, K Brown-Frandsen… - … England Journal of …, 2023 - Mass Medical Soc
Background Semaglutide, a glucagon-like peptide-1 receptor agonist, has been shown to
reduce the risk of adverse cardiovascular events in patients with diabetes. Whether …

Semaglutide improves cardiometabolic risk factors in adults with overweight or obesity: STEP 1 and 4 exploratory analyses

MN Kosiborod, M Bhatta, M Davies… - Diabetes, Obesity …, 2023 - Wiley Online Library
Aims Evaluate the effects of once‐weekly subcutaneous semaglutide 2.4 mg on
cardiometabolic risk factors in people with overweight/obesity without diabetes in the STEP …

Semaglutide and Cardiovascular Outcomes by Baseline HbA1c and Change in HbA1c in People With Overweight or Obesity but Without Diabetes in SELECT

I Lingvay, J Deanfield, SE Kahn, PE Weeke… - Diabetes …, 2024 - diabetesjournals.org
OBJECTIVE To evaluate the cardiovascular effects of semaglutide by baseline glycated
hemoglobin (HbA1c) and change in HbA1c in a prespecified analysis of Semaglutide Effects …

Long-term weight loss effects of semaglutide in obesity without diabetes in the SELECT trial

DH Ryan, I Lingvay, J Deanfield, SE Kahn, E Barros… - Nature medicine, 2024 - nature.com
In the SELECT cardiovascular outcomes trial, semaglutide showed a 20% reduction in major
adverse cardiovascular events in 17,604 adults with preexisting cardiovascular disease …

Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial

J Deanfield, S Verma, BM Scirica, SE Kahn… - The Lancet, 2024 - thelancet.com
Background Semaglutide, a GLP-1 receptor agonist, reduces the risk of major adverse
cardiovascular events (MACE) in people with overweight or obesity, but the effects of this …

Semaglutide for the treatment of obesity

AM Chao, JS Tronieri, A Amaro, TA Wadden - Trends in cardiovascular …, 2023 - Elsevier
Semaglutide is a glucagon-like peptide-1 receptor agonist that was recently approved by the
US Food and Drug Administration for chronic weight management. This paper reviews data …

Semaglutide for the treatment of overweight and obesity: a review

NC Bergmann, MJ Davies, I Lingvay… - Diabetes, Obesity and …, 2023 - Wiley Online Library
Obesity is a chronic, relapsing disease associated with multiple complications and a
substantial morbidity, mortality and health care burden. Pharmacological treatments for …