Acute obstruction of a coronary artery causes myocardial ischaemia and if prolonged, may
result in an ST-segment elevation myocardial infarction (STEMI). First-line treatment involves …

Myocardial infarction necessitates new therapeutic interventions, since it still results in high
morbidity and mortality worldwide. Reperfusion therapy itself results in (acceleration of) …

Abstract Ischemia/reperfusion (I/R) injury is an inflammatory condition that is characterized
by innate immunity and an adaptive immune response. This review is focused on the acute …

Introduction The immune system plays a crucial role in the initiation, development, and
resolution of inflammation following myocardial infarction (MI). The lack of oxygen and …

One of the major therapeutic challenges in the arena of interventional cardiology is to design
strategies aimed at reducing myocardial tissue damage after myocardial infarction. In …

Extensive necrosis of ischemic cardiomyocytes in the infarcted myocardium activates the
innate immune response triggering an intense inflammatory reaction. Release of danger …

Growing evidence indicates that overactivation and prolongation of the inflammatory
response after acute myocardial infarction (AMI) result in worse left ventricular remodelling …

The immune system plays a critical role in both repair and remodeling of the infarcted
myocardium. Danger signals released by dying cardiomyocytes mobilize, recruit, and …

Following acute occlusion of a coronary artery causing myocardial ischemia and
implementing first-line treatment involving rapid reperfusion, a dynamic and balanced …

Despite the advances that have been made in developing new therapeutics, cardiovascular
disease remains the leading cause of worldwide mortality. Therefore, understanding the …