Alteration of glycosylation, a hallmark of cancer, results in the production of tumor-
associated glycans or glycoproteins. These molecules are subsequently secreted or …

The lack of specific and sensitive tumour markers for early detection of cancer is driving a
search for new approaches that could identify biomarkers. Markers are needed to alert …

Glycoconjugates constitute a major class of biomolecules which include glycoproteins,
glycosphingolipids and proteoglycans. Glycans are involved in several physiological and …

Aberrant and dysregulated protein glycosylation is a well-established event in the process of
oncogenesis and cancer progression. Years of study on the glycobiology of cancer have …

Cancer is the second most common cause of death in developed countries with
approximately 14 million newly diagnosed individuals and over 6 million cancer‐related …

Protein glycosylation and other post-translational modifications are involved in potentially all
aspects of human growth and development. Defective glycosylation has adverse effects on …

Background: Cancer has profound effects on gene expression, including a cell's
glycosylation machinery. Thus, tumors produce glycoproteins that carry oligosaccharides …

Altered protein glycosylation compared with the disease-free state is a universal feature of
cancer cells. It has long been established that distinct glycan structures are associated with …

Glycosylation-mediated post-translational modification is critical for regulating many
fundamental processes like cell division, differentiation, immune response, and cell-to-cell …

The identification of serum biomarkers has lead to improvements in the detection and
diagnosis of cancer, and combinations of these biomarkers have increased further their …