Scalable flibanserin nanocrystal-based novel sublingual platform for female hypoactive sexual desire disorder: engineering, optimization adopting the desirability …

MJ Naguib, AIA Makhlouf - Drug Delivery, 2021 - Taylor & Francis
Flibanserin (FLB) was approved by FDA for the treatment of pre-menopausal female
hypoactive sexual desire disorder (HSDD). FLB suffers from low oral bioavailability (33%) …

RETRACTED: Application of Nanopharmaceutics for Flibanserin Brain Delivery Augmentation Via the Nasal Route

OAA Ahmed, UA Fahmy, SM Badr-Eldin, HM Aldawsari… - Nanomaterials, 2020 - mdpi.com
Flibanserin (FLB) is a nonhormonal medicine approved by the Food and Drug
Administration (FDA) to treat the hypoactive sexual appetite disorder in females. However …

RETRACTED: Intranasal Niosomal In Situ Gel as a Promising Approach for Enhancing Flibanserin Bioavailability and Brain Delivery: In Vitro Optimization and Ex Vivo …

UA Fahmy, SM Badr-Eldin, OAA Ahmed, HM Aldawsari… - Pharmaceutics, 2020 - mdpi.com
Flibanserin (FLB) is a multifunctional serotonergic agent that was recently approved by the
FDA for the oral treatment of premenopausal women with hypoactive sexual desire disorder …

Optimized nanostructured lipid carriers integrated into in situ nasal gel for enhancing brain delivery of flibanserin

UA Fahmy, OAA Ahmed, SM Badr-Eldin… - International journal …, 2020 - Taylor & Francis
Background and Aim Flibanserin (FLB) is a multifunctional serotonergic agent used for
treating hypoactive sexual desire disorder in premenopausal women via oral administration …

Spanlastics as a potential platform for enhancing the brain delivery of flibanserin: in vitro response-surface optimization and in vivo pharmacokinetics assessment

WS Alharbi, RH Hareeri, M Bazuhair, MA Alfaleh… - Pharmaceutics, 2022 - mdpi.com
Flibanserin was licensed by the United States Food and Drug Administration (FDA) as an
oral non-hormonal therapy for pre-menopausal women with inhibited sexual desire disorder …

Design and In Vitro Evaluation of Finasteride-Loaded Liquid Crystalline Nanoparticles for Topical Delivery

T Madheswaran, R Baskaran, RK Thapa, JY Rhyu… - Aaps Pharmscitech, 2013 - Springer
In this study, liquid crystalline nanoparticles (LCN) have been proposed as new carrier for
topical delivery of finasteride (FNS) in the treatment of androgenetic alopecia. To evaluate …

Pharmaceutical and pharmacological evaluation of the effect of nano-formulated spironolactone and progesterone on inflammation and hormonal levels for managing …

RI Amer, GE Yassin, RA Mohamed, AM Fayez - AAPS PharmSciTech, 2021 - Springer
Hirsutism is a dermatological condition that refers to the excessive growth of hair in
androgen-sensitive areas in women. Recently, the enhancement of the visible signs of a …

Darifenacin Self-assembled Liquid Crystal Cubic Nanoparticles: a Sustained Release Approach for an Overnight Control of Overactive Bladder

MM Farag, W El-Sebaie, EB Basalious… - AAPS …, 2023 - Springer
The current study is regarding the development and characterization of Darifenacin-loaded
self-assembled liquid crystal cubic nanoparticles (LCCN). An anhydrous approach was used …

Innovative berberine nanoethosomal vaginal in situ gel: Unraveling polycystic ovary syndrome treatment on female Wistar rats

S Usulkar, K Sutar, P Biradar, V Patil… - International Journal of …, 2024 - Elsevier
Purpose The present work seeks to develop, assess and refine a nanoethosomal vaginal in
situ gel containing Berberine, aimed at enhancing its efficacy in treating Poly Cystic Ovary …

Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: potential tool for the treatment of androgenic alopecia

H Hamishehkar, S Ghanbarzadeh… - Drug development …, 2016 - Taylor & Francis
Context: Flutamide is a potent anti-androgen with the several unwanted side effects in
systemic administration, therefore, it has attracted special interest in the development of …