Cancer is a process driven by the accumulation of abnormalities in gene function. While
many of these changes are genetic, epigenetically mediated changes in gene expression …

Gene function in cancer can be disrupted either through genetic alterations, which directly
mutate or delete genes, or epigenetic alterations, which alter the heritable state of gene …

DNA methylation, chromatin structure, transcription, and cancer have traditionally been
studied as separate phenomena. Recent data provide now direct physical and functional …

The cancer epigenome is characterised by specific DNA methylation and chromatin
modification patterns. The proteins that mediate these changes are encoded by the …

Epigenetic modifications are heritable changes in gene expression not encoded by the DNA
sequence. In the past decade, great strides have been made in characterizing epigenetic …

The field of epigenetics has recently moved to the forefront of studies relating to diverse
processes such as transcriptional regulation, chromatin structure, genome integrity, and …

DNA methylation alterations are now widely recognized as a contributing factor in human
tumorigenesis. A significant number of tumor suppressor genes are transcriptionally …

Aberrant DNA methylation of the promoter region is a key mechanism for inactivation of
genes that suppress tumorigenesis. Genes that are involved in every step of tumor formation …

Epigenetic regulation is the mechanism by which gene function is selectively activated or
inactivated in the cells. It provides higher-ordered and more specified genetic information …

Recently, the concept that epigenetic, as well as genetic, events might be central to the
evolution of human cancer is re-emerging. Cancers often exhibit an aberrant methylation of …