Emerging therapeutic targets for sepsis

EW Tindal, BE Armstead, SF Monaghan… - Expert opinion on …, 2021 - Taylor & Francis
Introduction: Sepsis is characterized by a dysregulated host response to infection. Sepsis-
associated morbidity/mortality demands concerted research efforts toward therapeutic …

[HTML][HTML] Evolving Paradigms in Sepsis Management: A Narrative Review

MJ Kim, EJ Choi, EJ Choi - Cells, 2024 - ncbi.nlm.nih.gov
Sepsis, a condition characterized by life-threatening organ dysfunction due to a
dysregulated host response to infection, significantly impacts global health, with mortality …

The enigma of sepsis

NC Riedemann, RF Guo… - The Journal of clinical …, 2003 - Am Soc Clin Investig
Sepsis remains a serious cause of morbidity and mortality, and the pathophysiology of the
disease is not clear. The definition of the clinical manifestations of sepsis is ever evolving …

The immunopathology of sepsis and potential therapeutic targets

T van der Poll, FL van de Veerdonk… - Nature Reviews …, 2017 - nature.com
Sepsis is defined as a life-threatening organ dysfunction that is caused by a dysregulated
host response to infection. In sepsis, the immune response that is initiated by an invading …

The pathogenesis and potential therapeutic targets in sepsis

W Zhang, H Jiang, G Wu, P Huang, H Wang, H An… - MedComm, 2023 - Wiley Online Library
Sepsis is defined as “a life‐threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection.” At present, sepsis continues to …

Sepsis: The evolution in definition, pathophysiology, and management

B Gyawali, K Ramakrishna… - SAGE open …, 2019 - journals.sagepub.com
There has been a significant evolution in the definition and management of sepsis over the
last three decades. This is driven in part due to the advances made in our understanding of …

Pathogenic, immunologic, and clinical aspects of sepsis–update 2016

F Uhle, BG Chousterman, R Gruetzmann… - Expert Review of Anti …, 2016 - Taylor & Francis
Introduction: Sepsis is a major cause of death worldwide but its orchestrating components
remain incompletely understood. On the one hand, development of sepsis results from an …

Signaling pathways and intervention therapies in sepsis

Y Zhang, B Ning - Signal Transduction and Targeted Therapy, 2021 - nature.com
Sepsis is defined as life-threatening organ dysfunction caused by dysregulated host
systemic inflammatory and immune response to infection. Over decades, advanced …

New therapies in sepsis

JL Vincent - Chest, 1997 - journal.chestnet.org
D espite recent improvements in intensive care monitoring, diagnostic techniques, and
therapies, sepsis remains common among the critically ill. Moreover, related mortality rates …

Pathophysiology of septic shock: From bench to bedside

KW McConnell, CM Coopersmith - La Presse Médicale, 2016 - Elsevier
Our understanding of sepsis and its resultant outcomes remains a paradox. On the one
hand, we know more about the pathophysiology of sepsis than ever before. However, this …