Eukaryotic cells face the challenging task of transporting a variety of particles through the
complex intracellular milieu in order to deliver, distribute, and mix the many components that …

Traffic-like collective movements are observed at almost all levels of biological systems.
Molecular motor proteins like, for example, kinesin and dynein, which are the vehicles of …

All substances exhibit constant random motion at the microscopic scale. This is a direct
consequence of thermal agitation, and leads to diffusion of molecules and small particles in …

The healthy growth and maintenance of a biological system depends on the precise spatial
organization of molecules within the cell through the dissipation of energy. Reaction …

Random motion within the cytoplasm gives rise to molecular diffusion; this motion is
essential to many biological processes. However, in addition to thermal Brownian motion …

Cells are the elementary units of living organisms, which are able to carry out many vital
functions. These functions rely on active processes on a microscopic scale. Therefore, they …

Early in evolution, the diversification of membrane-bound compartments that characterize
eukaryotic cells was accompanied by the elaboration of molecular machineries that mediate …

New technologies have emerged that enable the tracking of molecular motors and their
cargos with very high resolution both in vitro and in live cells. Classic in vitro motility assays …

Cell migration plays a crucial role in a variety of (patho) physiological processes such as
immune defense, wound healing, and formation of tumor metastases. Detailed models have …

Recent advances in cell biology enable precise molecular perturbations. The spatiotemporal
organization of cells and organisms, however, also depends on physical processes such as …