The RB tumor suppressor, a regulator of the cell cycle, apoptosis, senescence, and
differentiation, is frequently mutated in human cancers. We recently described an …

The retinoblastoma (RB) tumor suppressor family functions as a regulatory node governing
cell cycle progression, differentiation, and apoptosis. Post-translational modifications play a …

The retinoblastoma (RB) family transcriptional corepressors regulate diverse cellular events
including cell cycle, senescence, and differentiation. The activity and stability of these …

Retinoblastoma (RB) tumor suppressor proteins are important regulators of the cell cycle
and are implicated in a wide variety of human tumors. Genetic analysis of RB mutations in …

The Retinoblastoma (RB) transcriptional corepressor and related family of pocket proteins
play central roles in cell cycle control and development, and the regulatory networks …

Inactivation of the retinoblastoma gene Rb leads to defects in cell proliferation,
differentiation, or apoptosis, depending on specific cell or tissue types. To gain insights into …

Retinoblastoma tumor suppressor protein (pRb) regulates various biological processes
during development and tumorigenesis. Although the molecular mechanism by which pRb …

Retinoblastoma proteins are eukaryotic transcriptional corepressors that play central roles in
cell cycle control, among other functions. Although most metazoan genomes encode a …

Inactivation of the retinoblastoma protein (pRB) is a hallmark of human cancer. Accordingly
the RB pathway has been extensively studied in mammals, flies and worms, but mostly in …

Mutations in rbf1, the Drosophila homologue of the RB tumour suppressor gene, generate
defects in cell cycle control, cell death, and differentiation during development. Previous …